Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061689
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	9295
Post-QC gene number	1623
Post-QC cell number	8571

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Chondrocytes(Nos)_source	LAMB1_ligand	Adipocytes(Good)_target	ITGA6_ITGB4_receptor	1.825e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Adipocytes(Nos)_target	ITGA6_ITGB4_receptor	4.100e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	CD4+,T-cells(Good)_target	ITGA6_ITGB4_receptor	1.287e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	CD4+,T-cells(Nos)_target	ITGA6_ITGB4_receptor	6.018e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	ITGA6_ITGB4_receptor	6.040e-10	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Good)_target	ITGA6_ITGB4_receptor	2.822e-10	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	6.557e-09	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	HSC(Good)_target	ITGA6_ITGB4_receptor	3.399e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	HSC(Nos)_target	ITGA6_ITGB4_receptor	1.016e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Neutrophils(Nos)_target	ITGA6_ITGB4_receptor	3.916e-10	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Adipocytes(Good)_target	CD44_receptor	1.588e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Adipocytes(Nos)_target	CD44_receptor	2.054e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	CD4+,T-cells(Good)_target	CD44_receptor	6.013e-09	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	CD4+,T-cells(Nos)_target	CD44_receptor	6.568e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	CD44_receptor	1.552e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Good)_target	CD44_receptor	3.618e-09	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	1.562e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	HSC(Good)_target	CD44_receptor	2.313e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	HSC(Nos)_target	CD44_receptor	5.666e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Neutrophils(Nos)_target	CD44_receptor	2.116e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
CD4+,T-cells(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	4.429e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	1.594e-11	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.649e-11	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	3.395e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	1.222e-10	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	CD4+,T-cells(Good)_target	CDH1_receptor	1.503e-10	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	CD4+,T-cells(Good)_target	CDH1_receptor	5.407e-12	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	CD4+,T-cells(Good)_target	CDH1_receptor	1.238e-11	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	4.429e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	3.395e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Good)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	1.503e-10	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	9.681e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	3.483e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	1.065e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	7.975e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	1.594e-11	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	1.222e-10	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Good)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	5.407e-12	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	3.483e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	1.253e-11	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	3.832e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	2.869e-11	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	1.065e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	3.832e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	8.774e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	3.649e-11	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	1.238e-11	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	7.975e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	2.869e-11	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	8.774e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	6.570e-11	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514