Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061687
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	40427
Post-QC gene number	1674
Post-QC cell number	7456

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD4+,T-cells(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	2.800e-08	0.03	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	7.336e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	5.356e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	1.204e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	7.522e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Nos)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	3.635e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	6.434e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	4.043e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	3.820e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	CD46_ligand	Adipocytes(Good)_target	JAG1_receptor	1.783e-11	0.0	CD46	Cell-Cell Contact	PMID: 23086448
CD4+,T-cells(Nos)_source	CD46_ligand	Adipocytes(Nos)_target	JAG1_receptor	4.229e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Good)_source	CD46_ligand	CD4+,T-cells(Nos)_target	JAG1_receptor	1.728e-11	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Nos)_source	CD46_ligand	CD4+,T-cells(Nos)_target	JAG1_receptor	3.614e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
CD4+,T-cells(Nos)_source	CD46_ligand	CD4+,T-cells(Nos)_target	JAG1_receptor	2.624e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Good)_source	CD46_ligand	CD4+,T-cells(Nos)_target	JAG1_receptor	4.932e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Nos)_source	CD46_ligand	CD4+,T-cells(Nos)_target	JAG1_receptor	2.051e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Skeletal,muscle(Nos)_source	CD46_ligand	CD4+,T-cells(Nos)_target	JAG1_receptor	2.076e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
CD4+,T-cells(Nos)_source	CD46_ligand	Chondrocytes(Good)_target	JAG1_receptor	5.598e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
CD4+,T-cells(Nos)_source	CD46_ligand	Chondrocytes(Nos)_target	JAG1_receptor	2.256e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
CD4+,T-cells(Nos)_source	CD46_ligand	Skeletal,muscle(Nos)_target	JAG1_receptor	2.318e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448