Sample overview
| Project Name | Colon Adenocarcinoma |
| GSE ID | GSE201348 |
| GSM ID | GSM6061685 |
| Cell Line | None |
| Tissue type | Colon |
| Disease Type | Unaffected |
| PMID | 35726067 |
| Initial gene number | 33538 |
| Initial cell number | 3234 |
| Post-QC gene number | 2833 |
| Post-QC cell number | 3233 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Skeletal,muscle(Good)_source | PRSS3_ligand | Adipocytes(Nos)_target | PARD3_receptor | 6.155e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Adipocytes(Nos)_target | PARD3_receptor | 1.367e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 1.670e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 3.708e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 3.851e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 8.551e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 1.366e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| B-cells(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 6.239e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| CD4+,T-cells(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 2.270e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Monocytes(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 7.081e-07 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Skeletal,muscle(Good)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 1.035e-03 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Skeletal,muscle(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 2.294e-03 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Skeletal,muscle(Good)_source | APP_ligand | Monocytes(Nos)_target | CD74_receptor | 4.260e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Skeletal,muscle(Nos)_source | APP_ligand | Monocytes(Nos)_target | CD74_receptor | 9.438e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Adipocytes(Nos)_source | CD22_ligand | B-cells(Nos)_target | PTPRC_receptor | 2.911e-05 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | CD22_ligand | B-cells(Nos)_target | PTPRC_receptor | 6.248e-03 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CD22_ligand | B-cells(Nos)_target | PTPRC_receptor | 3.072e-05 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CD22_ligand | B-cells(Nos)_target | PTPRC_receptor | 6.983e-05 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CD22_ligand | CD4+,T-cells(Nos)_target | PTPRC_receptor | 1.032e-05 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | CD22_ligand | CD4+,T-cells(Nos)_target | PTPRC_receptor | 2.205e-03 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CD22_ligand | CD4+,T-cells(Nos)_target | PTPRC_receptor | 1.089e-05 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CD22_ligand | CD4+,T-cells(Nos)_target | PTPRC_receptor | 2.476e-05 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CD22_ligand | Monocytes(Nos)_target | PTPRC_receptor | 5.638e-07 | 0.01 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | CD22_ligand | Monocytes(Nos)_target | PTPRC_receptor | 1.274e-04 | 0.0 | CD22 | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | PTPRC_ligand | Adipocytes(Nos)_target | CD22_receptor | 2.911e-05 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| CD4+,T-cells(Nos)_source | PTPRC_ligand | Adipocytes(Nos)_target | CD22_receptor | 1.032e-05 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| Monocytes(Nos)_source | PTPRC_ligand | Adipocytes(Nos)_target | CD22_receptor | 5.638e-07 | 0.01 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| B-cells(Nos)_source | PTPRC_ligand | B-cells(Nos)_target | CD22_receptor | 6.248e-03 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| CD4+,T-cells(Nos)_source | PTPRC_ligand | B-cells(Nos)_target | CD22_receptor | 2.205e-03 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| Monocytes(Nos)_source | PTPRC_ligand | B-cells(Nos)_target | CD22_receptor | 1.274e-04 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| B-cells(Nos)_source | PTPRC_ligand | Skeletal,muscle(Good)_target | CD22_receptor | 3.072e-05 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| CD4+,T-cells(Nos)_source | PTPRC_ligand | Skeletal,muscle(Good)_target | CD22_receptor | 1.089e-05 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| B-cells(Nos)_source | PTPRC_ligand | Skeletal,muscle(Nos)_target | CD22_receptor | 6.983e-05 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| CD4+,T-cells(Nos)_source | PTPRC_ligand | Skeletal,muscle(Nos)_target | CD22_receptor | 2.476e-05 | 0.0 | CD45 | Cell-Cell Contact | PMID: 12115612 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 1.277e-05 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 2.936e-05 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 1.277e-05 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 1.596e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 3.669e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 2.936e-05 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 3.669e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 8.437e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | EFNA5_ligand | Adipocytes(Nos)_target | EPHB2_receptor | 1.492e-06 | 0.03 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNA5_ligand | Adipocytes(Nos)_target | EPHB2_receptor | 3.566e-06 | 0.03 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNA5_ligand | Adipocytes(Nos)_target | EPHB2_receptor | 9.662e-06 | 0.03 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Adipocytes(Nos)_source | EFNA5_ligand | Skeletal,muscle(Good)_target | EPHB2_receptor | 6.449e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNA5_ligand | Skeletal,muscle(Good)_target | EPHB2_receptor | 1.544e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNA5_ligand | Skeletal,muscle(Good)_target | EPHB2_receptor | 4.179e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Adipocytes(Nos)_source | EFNA5_ligand | Skeletal,muscle(Nos)_target | EPHB2_receptor | 1.330e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNA5_ligand | Skeletal,muscle(Nos)_target | EPHB2_receptor | 3.182e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNA5_ligand | Skeletal,muscle(Nos)_target | EPHB2_receptor | 8.615e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNB2_ligand | Adipocytes(Nos)_target | EPHB2_receptor | 2.786e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNB2_ligand | Adipocytes(Nos)_target | EPHB2_receptor | 6.481e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNB2_ligand | B-cells(Nos)_target | EPHB2_receptor | 2.182e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNB2_ligand | B-cells(Nos)_target | EPHB2_receptor | 5.076e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNB2_ligand | CD4+,T-cells(Nos)_target | EPHB2_receptor | 9.845e-07 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNB2_ligand | CD4+,T-cells(Nos)_target | EPHB2_receptor | 2.291e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Adipocytes(Nos)_source | EFNB2_ligand | Skeletal,muscle(Good)_target | EPHB2_receptor | 7.725e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNB2_ligand | Skeletal,muscle(Good)_target | EPHB2_receptor | 1.208e-04 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNB2_ligand | Skeletal,muscle(Good)_target | EPHB2_receptor | 2.810e-04 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Adipocytes(Nos)_source | EFNB2_ligand | Skeletal,muscle(Nos)_target | EPHB2_receptor | 1.591e-05 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Good)_source | EFNB2_ligand | Skeletal,muscle(Nos)_target | EPHB2_receptor | 2.488e-04 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Skeletal,muscle(Nos)_source | EFNB2_ligand | Skeletal,muscle(Nos)_target | EPHB2_receptor | 5.790e-04 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Adipocytes(Nos)_source | MPZL1_ligand | Adipocytes(Nos)_target | MPZL1_receptor | 7.577e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | MPZL1_ligand | Adipocytes(Nos)_target | MPZL1_receptor | 2.452e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | MPZL1_ligand | Adipocytes(Nos)_target | MPZL1_receptor | 4.745e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | MPZL1_ligand | B-cells(Nos)_target | MPZL1_receptor | 3.693e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | MPZL1_ligand | B-cells(Nos)_target | MPZL1_receptor | 7.143e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 4.143e-06 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 8.013e-06 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | MPZL1_ligand | Skeletal,muscle(Good)_target | MPZL1_receptor | 2.452e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | MPZL1_ligand | Skeletal,muscle(Good)_target | MPZL1_receptor | 3.693e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | Skeletal,muscle(Good)_target | MPZL1_receptor | 4.143e-06 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | MPZL1_ligand | Skeletal,muscle(Good)_target | MPZL1_receptor | 7.934e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | MPZL1_ligand | Skeletal,muscle(Good)_target | MPZL1_receptor | 1.535e-04 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | MPZL1_ligand | Skeletal,muscle(Nos)_target | MPZL1_receptor | 4.745e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | MPZL1_ligand | Skeletal,muscle(Nos)_target | MPZL1_receptor | 7.143e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | Skeletal,muscle(Nos)_target | MPZL1_receptor | 8.013e-06 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | MPZL1_ligand | Skeletal,muscle(Nos)_target | MPZL1_receptor | 1.535e-04 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | MPZL1_ligand | Skeletal,muscle(Nos)_target | MPZL1_receptor | 2.971e-04 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | OCLN_ligand | Adipocytes(Nos)_target | OCLN_receptor | 1.669e-08 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | OCLN_ligand | Adipocytes(Nos)_target | OCLN_receptor | 4.897e-08 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | OCLN_ligand | Adipocytes(Nos)_target | OCLN_receptor | 1.120e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | OCLN_ligand | Skeletal,muscle(Good)_target | OCLN_receptor | 4.897e-08 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | OCLN_ligand | Skeletal,muscle(Good)_target | OCLN_receptor | 1.437e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | OCLN_ligand | Skeletal,muscle(Good)_target | OCLN_receptor | 3.286e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | OCLN_ligand | Skeletal,muscle(Nos)_target | OCLN_receptor | 1.120e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | OCLN_ligand | Skeletal,muscle(Nos)_target | OCLN_receptor | 3.286e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | OCLN_ligand | Skeletal,muscle(Nos)_target | OCLN_receptor | 7.511e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 4.720e-05 | 0.02 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Good)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 6.278e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 1.315e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 1.216e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Good)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 1.615e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 3.382e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |