Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061676
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	3939
Post-QC gene number	1022
Post-QC cell number	3931

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Erythrocytes(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	7.705e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	1.925e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	6.136e-07	0.03	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	1.535e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Erythrocytes(Good)_target	PARD3_receptor	1.487e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Good)_source	PRSS3_ligand	Erythrocytes(Good)_target	PARD3_receptor	9.662e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Erythrocytes(Good)_target	PARD3_receptor	1.006e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Good)_source	PRSS3_ligand	Erythrocytes(Good)_target	PARD3_receptor	3.022e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Nos)_source	PRSS3_ligand	Erythrocytes(Good)_target	PARD3_receptor	2.505e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Good)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	6.492e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	6.736e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Good)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	2.029e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Nos)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	1.682e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Good)_source	PRSS3_ligand	Smooth,muscle(Good)_target	PARD3_receptor	1.411e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Smooth,muscle(Good)_target	PARD3_receptor	1.465e-05	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Good)_source	PRSS3_ligand	Smooth,muscle(Good)_target	PARD3_receptor	4.411e-06	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Nos)_source	PRSS3_ligand	Smooth,muscle(Good)_target	PARD3_receptor	3.657e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Smooth,muscle(Nos)_target	PARD3_receptor	1.820e-06	0.04	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Good)_source	PRSS3_ligand	Smooth,muscle(Nos)_target	PARD3_receptor	1.194e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Smooth,muscle(Nos)_target	PARD3_receptor	1.239e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Good)_source	PRSS3_ligand	Smooth,muscle(Nos)_target	PARD3_receptor	3.730e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Smooth,muscle(Nos)_source	PRSS3_ligand	Smooth,muscle(Nos)_target	PARD3_receptor	3.092e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Good)_source	LAMB1_ligand	Erythrocytes(Good)_target	CD44_receptor	7.909e-07	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Good)_source	LAMB1_ligand	Erythrocytes(Nos)_target	CD44_receptor	2.489e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Good)_source	LAMB1_ligand	Smooth,muscle(Good)_target	CD44_receptor	3.439e-08	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Good)_source	LAMB1_ligand	Smooth,muscle(Nos)_target	CD44_receptor	1.762e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	1.873e-07	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.741e-08	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	2.809e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	5.612e-07	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Erythrocytes(Good)_target	CDH1_receptor	6.785e-07	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Good)_source	CDH1_ligand	Erythrocytes(Good)_target	CDH1_receptor	1.355e-07	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	1.873e-07	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	2.809e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	6.785e-07	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	1.479e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Good)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	2.955e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	2.151e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Smooth,muscle(Good)_target	CDH1_receptor	3.741e-08	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Smooth,muscle(Good)_target	CDH1_receptor	5.612e-07	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	CDH1_ligand	Smooth,muscle(Good)_target	CDH1_receptor	1.355e-07	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Smooth,muscle(Good)_target	CDH1_receptor	2.955e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Good)_source	CDH1_ligand	Smooth,muscle(Good)_target	CDH1_receptor	5.905e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Nos)_source	CDH1_ligand	Smooth,muscle(Good)_target	CDH1_receptor	4.297e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Smooth,muscle(Nos)_target	CDH1_receptor	2.151e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Good)_source	CDH1_ligand	Smooth,muscle(Nos)_target	CDH1_receptor	4.297e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Smooth,muscle(Nos)_source	CDH1_ligand	Smooth,muscle(Nos)_target	CDH1_receptor	3.104e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514