Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061673
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	8277
Post-QC gene number	1484
Post-QC cell number	7143

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Neutrophils(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	1.046e-09	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	4.775e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	1.231e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	9.566e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	4.365e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	3.980e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	3.818e-08	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	1.742e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.622e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	7.403e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Neutrophils(Good)_target	PARD3_receptor	3.262e-10	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neutrophils(Good)_target	PARD3_receptor	1.489e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	2.409e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Good)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	1.951e-10	0.03	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	8.984e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	1.872e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	8.544e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	CD46_ligand	Adipocytes(Good)_target	JAG1_receptor	3.689e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Good)_source	CD46_ligand	Adipocytes(Nos)_target	JAG1_receptor	2.450e-12	0.04	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Nos)_source	CD46_ligand	Adipocytes(Nos)_target	JAG1_receptor	4.106e-11	0.04	CD46	Cell-Cell Contact	PMID: 23086448
Neutrophils(Nos)_source	CD46_ligand	Adipocytes(Nos)_target	JAG1_receptor	5.912e-11	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Neutrophils(Nos)_source	CD46_ligand	Chondrocytes(Good)_target	JAG1_receptor	8.519e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Neutrophils(Nos)_source	CD46_ligand	Chondrocytes(Nos)_target	JAG1_receptor	3.599e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Neutrophils(Nos)_source	CD46_ligand	Neutrophils(Good)_target	JAG1_receptor	1.530e-12	0.02	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Good)_source	CD46_ligand	Neutrophils(Nos)_target	JAG1_receptor	4.072e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Nos)_source	CD46_ligand	Neutrophils(Nos)_target	JAG1_receptor	6.825e-11	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Good)_source	CD46_ligand	Neutrophils(Nos)_target	JAG1_receptor	9.089e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Nos)_source	CD46_ligand	Neutrophils(Nos)_target	JAG1_receptor	4.341e-10	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Neutrophils(Good)_source	CD46_ligand	Neutrophils(Nos)_target	JAG1_receptor	1.675e-12	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Neutrophils(Nos)_source	CD46_ligand	Neutrophils(Nos)_target	JAG1_receptor	9.827e-11	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Adipocytes(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.387e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.466e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	4.538e-09	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	1.993e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	1.899e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	7.951e-09	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	5.845e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	3.466e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	5.965e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	4.538e-09	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	7.810e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	1.993e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	3.431e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	1.899e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	3.268e-08	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neutrophils(Good)_target	CDH1_receptor	7.951e-09	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Good)_target	CDH1_receptor	1.369e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	5.845e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	5.965e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	7.810e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	3.431e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	3.268e-08	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	1.369e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	1.008e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514