Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061671
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	7595
Post-QC gene number	1841
Post-QC cell number	7289

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Endothelial,cells(Nos)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	3.232e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	CD4+,T-cells(Nos)_target	PARD3_receptor	1.974e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Endothelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	1.359e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	8.301e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Endothelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	4.450e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	2.718e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	PRSS3_ligand	Endothelial,cells(Nos)_target	PARD3_receptor	2.369e-08	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Good)_source	PRSS3_ligand	Endothelial,cells(Nos)_target	PARD3_receptor	1.621e-08	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Nos)_source	PRSS3_ligand	Endothelial,cells(Nos)_target	PARD3_receptor	4.453e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Endothelial,cells(Nos)_source	PRSS3_ligand	Endothelial,cells(Nos)_target	PARD3_receptor	5.750e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Endothelial,cells(Nos)_target	PARD3_receptor	3.500e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Good)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	5.321e-10	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	1.462e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Endothelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	1.897e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	1.158e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	1.272e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	2.926e-09	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	1.471e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	8.373e-08	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	4.208e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Endothelial,cells(Nos)_target	CDH1_receptor	2.926e-09	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Endothelial,cells(Nos)_target	CDH1_receptor	8.373e-08	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CDH1_ligand	Endothelial,cells(Nos)_target	CDH1_receptor	5.428e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Endothelial,cells(Nos)_target	CDH1_receptor	2.727e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.272e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.471e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	4.208e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	2.727e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.359e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514