Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061657
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	22742
Post-QC gene number	4080
Post-QC cell number	21747

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Neutrophils(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	1.608e-10	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	9.891e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	2.395e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Good)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	1.004e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	9.215e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	3.358e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	8.189e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.743e-09	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.517e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	9.190e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.237e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	2.601e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	1.029e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	2.927e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	1.158e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	2.601e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	2.927e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	3.549e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	1.404e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.029e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.158e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.404e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	5.557e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	ITGA2_ITGB1_receptor	2.990e-09	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Skeletal,muscle(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	ITGA2_ITGB1_receptor	1.183e-09	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Neutrophils(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	ITGA2_ITGB1_receptor	2.498e-07	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Skeletal,muscle(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	ITGA2_ITGB1_receptor	9.886e-08	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	ITGA2_ITGB1_receptor	1.429e-09	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Skeletal,muscle(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	ITGA2_ITGB1_receptor	5.654e-10	0.02	CDH1	Cell-Cell Contact	PMID: 12392763
Chondrocytes(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	ITGA2_ITGB1_receptor	1.239e-09	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Chondrocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	ITGA2_ITGB1_receptor	1.394e-07	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Neutrophils(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	ITGA2_ITGB1_receptor	1.690e-08	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	ITGA2_ITGB1_receptor	6.688e-09	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHA4_receptor	6.292e-14	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHA4_receptor	2.323e-13	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	8.661e-12	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	3.198e-11	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	1.996e-13	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	2.748e-11	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	1.493e-12	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	5.511e-12	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	7.102e-13	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	9.779e-11	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	5.311e-12	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	1.961e-11	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHB2_receptor	9.834e-12	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHB2_receptor	3.631e-11	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	9.085e-10	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	3.354e-09	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHB2_receptor	7.560e-12	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHB2_receptor	2.791e-11	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	2.745e-10	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	3.779e-08	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	2.053e-09	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Skeletal,muscle(Nos)_source	EFNA5_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	7.578e-09	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHA4_receptor	1.167e-12	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHA4_receptor	4.135e-12	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	1.607e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	5.693e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	7.844e-13	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	8.693e-11	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	2.769e-11	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	9.810e-11	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	2.791e-12	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	3.093e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	9.853e-11	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHA4_receptor	3.491e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHB2_receptor	1.824e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHB2_receptor	6.463e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	1.685e-08	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	5.971e-08	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHB2_receptor	1.402e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHB2_receptor	4.969e-10	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	1.079e-09	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	1.195e-07	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	3.807e-08	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Skeletal,muscle(Nos)_source	EFNB2_ligand	Skeletal,muscle(Nos)_target	EPHB2_receptor	1.349e-07	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	MPZL1_ligand	Chondrocytes(Nos)_target	MPZL1_receptor	3.437e-09	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	MPZL1_ligand	Chondrocytes(Nos)_target	MPZL1_receptor	1.400e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	MPZL1_ligand	Neutrophils(Nos)_target	MPZL1_receptor	3.437e-09	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	MPZL1_ligand	Neutrophils(Nos)_target	MPZL1_receptor	2.089e-10	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	MPZL1_ligand	Neutrophils(Nos)_target	MPZL1_receptor	8.507e-10	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	MPZL1_ligand	Skeletal,muscle(Nos)_target	MPZL1_receptor	1.400e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	MPZL1_ligand	Skeletal,muscle(Nos)_target	MPZL1_receptor	8.507e-10	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	MPZL1_ligand	Skeletal,muscle(Nos)_target	MPZL1_receptor	3.464e-09	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	OCLN_ligand	Chondrocytes(Good)_target	OCLN_receptor	2.914e-12	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	OCLN_ligand	Chondrocytes(Good)_target	OCLN_receptor	9.121e-12	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	OCLN_ligand	Chondrocytes(Nos)_target	OCLN_receptor	2.904e-10	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	OCLN_ligand	Chondrocytes(Nos)_target	OCLN_receptor	9.091e-10	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	OCLN_ligand	Neutrophils(Nos)_target	OCLN_receptor	2.914e-12	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	OCLN_ligand	Neutrophils(Nos)_target	OCLN_receptor	2.904e-10	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	OCLN_ligand	Neutrophils(Nos)_target	OCLN_receptor	2.584e-11	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	OCLN_ligand	Neutrophils(Nos)_target	OCLN_receptor	8.089e-11	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	OCLN_ligand	Skeletal,muscle(Nos)_target	OCLN_receptor	9.121e-12	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	OCLN_ligand	Skeletal,muscle(Nos)_target	OCLN_receptor	9.091e-10	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	OCLN_ligand	Skeletal,muscle(Nos)_target	OCLN_receptor	8.089e-11	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	OCLN_ligand	Skeletal,muscle(Nos)_target	OCLN_receptor	2.532e-10	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514