Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061655
Cell Line	None
Tissue type	Colon
Disease Type	Unaffected
PMID	35726067
Initial gene number	33538
Initial cell number	4788
Post-QC gene number	1200
Post-QC cell number	4703

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Mesangial,cells(Nos)_source	PRSS3_ligand	HSC(Nos)_target	PARD3_receptor	1.623e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	HSC(Nos)_target	PARD3_receptor	4.701e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Mesangial,cells(Nos)_source	PRSS3_ligand	Mesangial,cells(Nos)_target	PARD3_receptor	3.630e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Mesangial,cells(Nos)_target	PARD3_receptor	1.051e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Mesangial,cells(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	9.229e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	2.673e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Mesangial,cells(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.992e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	8.669e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Mesangial,cells(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	2.096e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	CD4+,T-cells(Nos)_target	CDH1_receptor	8.974e-08	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	3.604e-07	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	1.543e-07	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	Mesangial,cells(Good)_target	CDH1_receptor	3.618e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Mesangial,cells(Good)_target	CDH1_receptor	1.549e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	2.096e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	3.604e-07	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Good)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	3.618e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	1.086e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	8.773e-08	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	2.807e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	4.645e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	8.773e-08	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	3.756e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	2.807e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	1.202e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	8.974e-08	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.543e-07	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.549e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	4.645e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	3.756e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.202e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.985e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	SEMA6A_ligand	CD4+,T-cells(Good)_target	PLXNA2_receptor	1.871e-09	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	CD4+,T-cells(Good)_target	PLXNA2_receptor	5.839e-10	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	CD4+,T-cells(Nos)_target	PLXNA2_receptor	2.066e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	CD4+,T-cells(Nos)_target	PLXNA2_receptor	6.447e-09	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	HSC(Good)_target	PLXNA2_receptor	1.439e-09	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	HSC(Good)_target	PLXNA2_receptor	4.489e-10	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	HSC(Nos)_target	PLXNA2_receptor	5.996e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	HSC(Nos)_target	PLXNA2_receptor	1.871e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	Mesangial,cells(Good)_target	PLXNA2_receptor	2.301e-09	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Mesangial,cells(Good)_target	PLXNA2_receptor	7.180e-10	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Good)_source	SEMA6A_ligand	Mesangial,cells(Nos)_target	PLXNA2_receptor	2.318e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	Mesangial,cells(Nos)_target	PLXNA2_receptor	9.031e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Mesangial,cells(Nos)_target	PLXNA2_receptor	2.818e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	Neurons(Good)_target	PLXNA2_receptor	5.499e-09	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Neurons(Good)_target	PLXNA2_receptor	1.716e-09	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	2.472e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	7.714e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	4.549e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Mesangial,cells(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	1.769e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	5.517e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782