Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061647
Cell Line	None
Tissue type	Colon
Disease Type	Unaffected
PMID	35726067
Initial gene number	33538
Initial cell number	2396
Post-QC gene number	989
Post-QC cell number	2230

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Adipocytes(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	2.097e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	7.432e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	3.509e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	6.323e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	3.083e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	4.903e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	6.953e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	2.413e-03	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	2.094e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	1.052e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	1.649e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	1.941e-05	0.03	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	4.602e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	7.225e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	2.571e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.211e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	2.179e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.057e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.685e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	2.346e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	8.412e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	3.945e-06	0.04	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	7.079e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	3.398e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	5.445e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	3.906e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	1.389e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	6.546e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	1.178e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	5.720e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	9.115e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.965e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	2.617e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	8.315e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	9.172e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.607e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	6.443e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	2.617e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	1.710e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	5.486e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	2.383e-06	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	4.250e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	8.315e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	5.486e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.744e-06	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	7.566e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.351e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	9.172e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	1.490e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	3.607e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	2.383e-06	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	7.566e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	5.863e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	6.443e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	4.250e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.351e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.490e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	5.863e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.047e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	4.815e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Nos)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	3.496e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	1.023e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	1.546e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	1.315e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	2.039e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Good)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	7.533e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Nos)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	5.463e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	2.420e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	2.125e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	3.259e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	9.005e-07	0.01	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	7.909e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	1.213e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Good)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	5.137e-06	0.01	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	1.649e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	1.392e-06	0.02	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	2.164e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	1.024e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	7.440e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	2.176e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	3.289e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	2.776e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	4.317e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782