Sample overview

Project Name	Colon Adenocarcinoma
GSE ID	GSE201348
GSM ID	GSM6061647
Cell Line	None
Tissue type	Colon
Disease Type	Unaffected
PMID	35726067
Initial gene number	33538
Initial cell number	2396
Post-QC gene number	989
Post-QC cell number	2230

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Adipocytes(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	2.097e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	7.432e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	3.509e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	6.323e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	3.083e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Adipocytes(Good)_target	PARD3_receptor	4.903e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	6.953e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	2.413e-03	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	2.094e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	1.052e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Adipocytes(Nos)_target	PARD3_receptor	1.649e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	1.941e-05	0.03	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	4.602e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	7.225e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	2.571e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.211e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	2.179e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.057e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.685e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	2.346e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	8.412e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	3.945e-06	0.04	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	7.079e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	3.398e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Good)_target	PARD3_receptor	5.445e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	3.906e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	1.389e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	6.546e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	1.178e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	5.720e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	9.115e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Adipocytes(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.965e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	2.617e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	8.315e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	9.172e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	3.607e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Adipocytes(Good)_target	CDH1_receptor	6.443e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	2.617e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	1.710e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	5.486e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	2.383e-06	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Adipocytes(Nos)_target	CDH1_receptor	4.250e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	8.315e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	5.486e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.744e-06	0.03	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	7.566e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.351e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	9.172e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	1.490e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	3.607e-06	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	2.383e-06	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	7.566e-07	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	5.863e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	6.443e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	4.250e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.351e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.490e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	5.863e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.047e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Good)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	4.815e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Nos)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	3.496e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	1.023e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	1.546e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	1.315e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Adipocytes(Good)_target	PLXNA2_receptor	2.039e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Good)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	7.533e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Nos)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	5.463e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	2.420e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	2.125e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Adipocytes(Nos)_target	PLXNA2_receptor	3.259e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	9.005e-07	0.01	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	7.909e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	1.213e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Good)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	5.137e-06	0.01	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	1.649e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	1.392e-06	0.02	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	2.164e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	1.024e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Adipocytes(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	7.440e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	2.176e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	3.289e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	2.776e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Skeletal,muscle(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	4.317e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782