Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061646
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	3842
Post-QC gene number	2654
Post-QC cell number	3827

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	3.751e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	2.387e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	3.493e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Chondrocytes(Nos)_target	PARD3_receptor	2.222e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	4.046e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	2.575e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Chondrocytes(Good)_source	CD46_ligand	Chondrocytes(Nos)_target	JAG1_receptor	3.773e-07	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Nos)_source	CD46_ligand	Chondrocytes(Nos)_target	JAG1_receptor	3.232e-06	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Good)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	4.024e-05	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Chondrocytes(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	3.451e-04	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	5.928e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	CDH1_receptor	3.727e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	CDH1_receptor	5.630e-04	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	5.928e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	5.630e-04	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.059e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	6.660e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	3.727e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	6.660e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	4.187e-05	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Good)_target	ITGA2_ITGB1_receptor	2.150e-05	0.03	CDH1	Cell-Cell Contact	PMID: 12392763
Chondrocytes(Good)_source	CDH1_ligand	Chondrocytes(Nos)_target	ITGA2_ITGB1_receptor	1.538e-04	0.01	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	ITGA2_ITGB1_receptor	2.751e-04	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Neurons(Nos)_source	CDH1_ligand	Chondrocytes(Nos)_target	ITGA2_ITGB1_receptor	1.729e-04	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Chondrocytes(Good)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHA4_receptor	9.320e-07	0.03	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHA4_receptor	1.751e-06	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHA4_receptor	3.350e-07	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHA4_receptor	2.645e-07	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	9.146e-06	0.03	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	1.718e-05	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	3.288e-06	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	2.595e-06	0.03	EPHA	Cell-Cell Contact	PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	4.020e-07	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Neurons(Nos)_target	EPHA4_receptor	2.860e-07	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	2.404e-07	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	4.517e-07	0.02	EPHA	Cell-Cell Contact	PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	8.642e-08	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Neutrophils(Nos)_target	EPHA4_receptor	6.823e-08	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHB2_receptor	6.607e-06	0.03	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHB2_receptor	2.362e-06	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Good)_target	EPHB2_receptor	1.874e-06	0.02	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Chondrocytes(Good)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	7.467e-05	0.02	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Chondrocytes(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	1.404e-04	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	2.669e-05	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	2.118e-05	0.01	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neurons(Good)_source	EFNA5_ligand	Neurons(Nos)_target	EPHB2_receptor	2.269e-06	0.0	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Neutrophils(Nos)_source	EFNA5_ligand	Neurons(Nos)_target	EPHB2_receptor	1.800e-06	0.04	EPHA	Cell-Cell Contact	PMID:15107857; PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHA4_receptor	1.308e-06	0.02	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHA4_receptor	9.765e-06	0.01	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHA4_receptor	1.738e-06	0.02	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHA4_receptor	1.284e-05	0.01	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	3.375e-07	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	2.519e-06	0.02	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB2_ligand	Neutrophils(Nos)_target	EPHA4_receptor	4.484e-07	0.02	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Chondrocytes(Good)_target	EPHB2_receptor	9.269e-06	0.02	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	1.047e-04	0.01	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB2_ligand	Chondrocytes(Nos)_target	EPHB2_receptor	1.392e-04	0.04	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Good)_source	EFNB2_ligand	Neurons(Nos)_target	EPHB2_receptor	8.901e-06	0.03	EPHB	Cell-Cell Contact	PMID: 15114347
Chondrocytes(Nos)_source	MPZL1_ligand	Chondrocytes(Nos)_target	MPZL1_receptor	2.054e-05	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	OCLN_ligand	Chondrocytes(Good)_target	OCLN_receptor	1.479e-08	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	OCLN_ligand	Chondrocytes(Good)_target	OCLN_receptor	1.507e-07	0.01	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	OCLN_ligand	Chondrocytes(Good)_target	OCLN_receptor	1.488e-08	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	OCLN_ligand	Chondrocytes(Nos)_target	OCLN_receptor	1.507e-07	0.01	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	OCLN_ligand	Chondrocytes(Nos)_target	OCLN_receptor	1.517e-07	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Good)_source	OCLN_ligand	Neurons(Nos)_target	OCLN_receptor	1.488e-08	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	OCLN_ligand	Neurons(Nos)_target	OCLN_receptor	1.517e-07	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	OCLN_ligand	Neurons(Nos)_target	OCLN_receptor	1.497e-08	0.04	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA6A_ligand	Chondrocytes(Nos)_target	PLXNA2_receptor	1.942e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Chondrocytes(Nos)_target	PLXNA2_receptor	1.054e-05	0.03	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Chondrocytes(Nos)_target	PLXNA2_receptor	1.529e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Epithelial,cells(Nos)_target	PLXNA2_receptor	1.350e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Epithelial,cells(Nos)_target	PLXNA2_receptor	7.315e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Epithelial,cells(Nos)_target	PLXNA2_receptor	1.061e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	1.852e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Good)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	1.005e-06	0.04	SEMA6	Cell-Cell Contact	PMID: 27533782
Neurons(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	1.458e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782