Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061645
Cell Line	None
Tissue type	Colon
Disease Type	CRC
PMID	35726067
Initial gene number	33538
Initial cell number	1651
Post-QC gene number	1327
Post-QC cell number	1603

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Good)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	1.166e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	5.634e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	6.828e-05	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Chondrocytes(Good)_target	PARD3_receptor	5.224e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	PRSS3_ligand	Epithelial,cells(Good)_target	PARD3_receptor	8.086e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Good)_target	PARD3_receptor	3.883e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Epithelial,cells(Good)_target	PARD3_receptor	4.694e-04	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Epithelial,cells(Good)_target	PARD3_receptor	3.624e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	6.345e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	3.045e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	2.844e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	4.829e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.334e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.828e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Skeletal,muscle(Nos)_source	PRSS3_ligand	Skeletal,muscle(Nos)_target	PARD3_receptor	2.164e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	CDH1_ligand	Epithelial,cells(Good)_target	CDH1_receptor	5.853e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Good)_target	CDH1_receptor	1.543e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Good)_target	CDH1_receptor	4.772e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Epithelial,cells(Good)_target	CDH1_receptor	2.942e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.543e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	3.984e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.257e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	7.787e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	4.772e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	1.257e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	3.891e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	2.399e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	2.942e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	7.787e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	2.399e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	1.477e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514