Sample overview

Project Name	Breast Invasive Carcinoma
GSE ID	GSE227244
GSM ID	GSM7093771
Cell Line	T47D
Tissue type	None
Disease Type	Ductal carcinoma, mammary gland
PMID	38663407
Initial gene number	33538
Initial cell number	18188
Post-QC gene number	11866
Post-QC cell number	6914

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Good)_target	BMPR1A_ACVR2B_receptor	3.059e-06	0.02	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1A_ACVR2B_receptor	1.436e-05	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Good)_target	BMPR1A_BMPR2_receptor	1.405e-05	0.02	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1A_BMPR2_receptor	6.401e-05	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1B_ACVR2B_receptor	4.068e-06	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1B_BMPR2_receptor	1.814e-05	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	INHBB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	7.347e-05	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04353
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC2_receptor	6.625e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC2_receptor	2.678e-02	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC2_receptor	1.237e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC2_receptor	5.004e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Good)_target	SDC4_receptor	5.507e-04	0.01	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.734e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	5.400e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	2.172e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Good)_target	ITGA6_ITGB1_receptor	7.709e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	3.847e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	ITGA6_ITGB1_receptor	7.231e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Poor)_target	ITGA6_ITGB1_receptor	2.913e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Good)_target	NCL_receptor	1.737e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Good)_target	NCL_receptor	7.037e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	NCL_receptor	7.799e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	NCL_receptor	1.321e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	SEMA3C_ligand	Epithelial,cells(Good)_target	PLXND1_receptor	5.403e-05	0.01	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Good)_target	PLXND1_receptor	2.320e-04	0.01	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Poor)_source	SEMA3C_ligand	Epithelial,cells(Good)_target	PLXND1_receptor	3.259e-05	0.02	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Good)_target	SDC4_receptor	5.665e-05	0.03	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.815e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	5.577e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	2.256e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	4.442e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Poor)_target	CD47_receptor	9.143e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Poor)_target	CD47_receptor	3.699e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	CADM1_ligand	Epithelial,cells(Good)_target	CADM1_receptor	1.745e-04	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Nos)_source	CADM1_ligand	Epithelial,cells(Good)_target	CADM1_receptor	6.953e-04	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Good)_source	CADM1_ligand	Epithelial,cells(Nos)_target	CADM1_receptor	6.953e-04	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Nos)_source	L1CAM_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	1.048e-04	0.0	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Poor)_source	L1CAM_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	1.898e-05	0.0	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Nos)_source	L1CAM_ligand	Epithelial,cells(Poor)_target	L1CAM_receptor	1.898e-05	0.0	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Poor)_source	L1CAM_ligand	Epithelial,cells(Poor)_target	L1CAM_receptor	3.435e-06	0.04	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Good)_source	NCAM2_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	3.800e-04	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	NCAM2_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	1.707e-03	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	NCAM2_ligand	Epithelial,cells(Poor)_target	L1CAM_receptor	6.878e-05	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514