Sample overview

Project Name	TCGA-BRCA
GSE ID	GSE227244
GSM ID	GSM7093771
Cell Line	T47D
Tissue type	None
Disease Type	Ductal carcinoma, mammary gland
PMID	38663407
Initial gene number	33538
Initial cell number	18188
Post-QC gene number	11866
Post-QC cell number	6914

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Good)_target	BMPR1A_ACVR2B_receptor	3.059e-06	0.02	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1A_ACVR2B_receptor	1.436e-05	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Good)_target	BMPR1A_BMPR2_receptor	1.405e-05	0.02	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1A_BMPR2_receptor	6.401e-05	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1B_ACVR2B_receptor	4.068e-06	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Good)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1B_BMPR2_receptor	1.814e-05	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	INHBB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	7.347e-05	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04353
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC2_receptor	6.625e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC2_receptor	2.678e-02	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC2_receptor	1.237e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC2_receptor	5.004e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Good)_target	SDC4_receptor	5.507e-04	0.01	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.734e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	5.400e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	2.172e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Good)_target	ITGA6_ITGB1_receptor	7.709e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	3.847e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	ITGA6_ITGB1_receptor	7.231e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Poor)_target	ITGA6_ITGB1_receptor	2.913e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Good)_target	NCL_receptor	1.737e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Good)_target	NCL_receptor	7.037e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	NCL_receptor	7.799e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Poor)_target	NCL_receptor	1.321e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	SEMA3C_ligand	Epithelial,cells(Good)_target	PLXND1_receptor	5.403e-05	0.01	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Good)_target	PLXND1_receptor	2.320e-04	0.01	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Poor)_source	SEMA3C_ligand	Epithelial,cells(Good)_target	PLXND1_receptor	3.259e-05	0.02	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Good)_target	SDC4_receptor	5.665e-05	0.03	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.815e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	5.577e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Poor)_target	SDC4_receptor	2.256e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	4.442e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	THBS1_ligand	Epithelial,cells(Poor)_target	CD47_receptor	9.143e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Poor)_target	CD47_receptor	3.699e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	CADM1_ligand	Epithelial,cells(Good)_target	CADM1_receptor	1.745e-04	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Nos)_source	CADM1_ligand	Epithelial,cells(Good)_target	CADM1_receptor	6.953e-04	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Good)_source	CADM1_ligand	Epithelial,cells(Nos)_target	CADM1_receptor	6.953e-04	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Nos)_source	L1CAM_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	1.048e-04	0.0	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Poor)_source	L1CAM_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	1.898e-05	0.0	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Nos)_source	L1CAM_ligand	Epithelial,cells(Poor)_target	L1CAM_receptor	1.898e-05	0.0	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Poor)_source	L1CAM_ligand	Epithelial,cells(Poor)_target	L1CAM_receptor	3.435e-06	0.04	L1CAM	Cell-Cell Contact	PMID: 18701456
Epithelial,cells(Good)_source	NCAM2_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	3.800e-04	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	NCAM2_ligand	Epithelial,cells(Nos)_target	L1CAM_receptor	1.707e-03	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	NCAM2_ligand	Epithelial,cells(Poor)_target	L1CAM_receptor	6.878e-05	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514