Sample overview

Project Name	TCGA-BRCA
GSE ID	GSE182694
GSM ID	GSM5534782
Cell Line	T47D
Tissue type	None
Disease Type	Estrogen Receptor-positive (ER+), HER2-negative
PMID	\
Initial gene number	33538
Initial cell number	5539
Post-QC gene number	10136
Post-QC cell number	4449

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1A_ACVR2B_receptor	9.136e-05	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP4_ligand	Epithelial,cells(Nos)_target	BMPR1A_BMPR2_receptor	3.975e-04	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Good)_target	TGFBR1_ACVR2B_receptor	2.056e-06	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Nos)_target	TGFBR1_ACVR2B_receptor	7.971e-05	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Poor)_target	TGFBR1_ACVR2B_receptor	6.503e-07	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Good)_target	ACVR1B_ACVR2B_receptor	1.223e-06	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	3.185e-05	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Poor)_target	ACVR1B_ACVR2B_receptor	1.902e-07	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	INHBB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	2.105e-04	ACTIVIN	Secreted Signaling	KEGG: hsa04353
Epithelial,cells(Nos)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_receptor	2.070e-05	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Nos)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_ERBB2_receptor	7.201e-05	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Nos)_source	TNFSF10_ligand	Epithelial,cells(Nos)_target	TNFRSF10A_receptor	9.288e-05	TRAIL	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	6.871e-05	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	1.622e-03	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	8.100e-03	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	4.120e-02	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.431e-02	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	PLXND1_receptor	3.780e-03	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	3.371e-02	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.205e-03	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	4.232e-04	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	4.370e-04	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	8.884e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	9.582e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	4.682e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	5.052e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	4.547e-04	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	6.324e-04	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	7.128e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	7.689e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	ITGAV_ITGB1_receptor	3.980e-04	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	5.239e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	5.653e-03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	6.126e-06	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	9.155e-06	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	CD44_receptor	6.813e-05	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	7.355e-05	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	3.152e-04	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	2.109e-04	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	2.266e-04	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.671e-03	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.119e-03	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.202e-03	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	4.747e-04	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	AGRN_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.591e-02	AGRN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	HSPG2_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	2.168e-04	HSPG	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.247e-02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.344e-02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	1.043e-02	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.947e-02	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.351e-02	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	EFNA3_ligand	Epithelial,cells(Nos)_target	EPHA1_receptor	8.770e-04	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA3_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	3.678e-04	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA5_ligand	Epithelial,cells(Nos)_target	EPHA1_receptor	2.471e-04	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA5_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	1.036e-04	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	7.065e-05	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Good)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB3_receptor	7.092e-06	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB3_receptor	1.083e-04	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Poor)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB3_receptor	6.918e-07	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB4_receptor	5.791e-05	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB3_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	8.799e-05	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Good)_source	EFNB3_ligand	Epithelial,cells(Nos)_target	EPHB3_receptor	1.096e-05	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB3_ligand	Epithelial,cells(Nos)_target	EPHB3_receptor	1.349e-04	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Poor)_source	EFNB3_ligand	Epithelial,cells(Nos)_target	EPHB3_receptor	1.149e-06	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNB3_ligand	Epithelial,cells(Nos)_target	EPHB4_receptor	7.213e-05	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	F11R_ligand	Epithelial,cells(Nos)_target	F11R_receptor	2.078e-02	JAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	2.585e-03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	NECTIN1_ligand	Epithelial,cells(Nos)_target	NECTIN4_receptor	2.098e-03	NECTIN	Cell-Cell Contact	PMID: 23027581
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	1.282e-07	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA4D_ligand	Epithelial,cells(Nos)_target	PLXNB1_receptor	2.958e-04	SEMA4	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA4D_ligand	Epithelial,cells(Nos)_target	PLXNB2_receptor	1.548e-03	SEMA4	Cell-Cell Contact	PMID: 27533782