Sample overview

Project Name	TCGA-BRCA
GSE ID	GSE182694
GSM ID	GSM5534770
Cell Line	MCF7s1r2
Tissue type	None
Disease Type	Estrogen Receptor-positive (ER+), HER2-negative
PMID	\
Initial gene number	33538
Initial cell number	2683
Post-QC gene number	6015
Post-QC cell number	2095

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Good)_source	GDF15_ligand	Epithelial,cells(Nos)_target	TGFBR2_receptor	8.601e-05	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF15_ligand	Epithelial,cells(Nos)_target	TGFBR2_receptor	2.669e-04	0.03	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Good)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	2.278e-05	0.04	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	9.383e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	NRP1_PLXNA1_receptor	3.408e-03	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	NRP2_PLXNA1_receptor	9.529e-04	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	NRP1_NRP2_receptor	1.382e-03	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	PLXND1_receptor	2.876e-03	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	3.694e-02	0.0	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	PSAP_ligand	Epithelial,cells(Nos)_target	GPR37L1_receptor	1.110e-02	0.0	PSAP	Secreted Signaling	PMID: 23690594
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	1.769e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	2.629e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	4.116e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	6.125e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	AGRN_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	9.205e-03	0.0	AGRN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.693e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	2.517e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	6.638e-05	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	1.415e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.800e-02	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB4_receptor	7.575e-04	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	F11R_ligand	Epithelial,cells(Nos)_target	F11R_receptor	1.644e-03	0.0	JAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	5.696e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	JAG1_ligand	Epithelial,cells(Nos)_target	NOTCH2_receptor	1.529e-04	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG1_ligand	Epithelial,cells(Nos)_target	NOTCH3_receptor	7.571e-05	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	2.019e-04	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA5A_ligand	Epithelial,cells(Nos)_target	PLXNA1_receptor	1.136e-03	0.0	SEMA5	Cell-Cell Contact	PMID: 27533782