Sample overview

Project Name	TCGA-BRCA
GSE ID	GSE182694
GSM ID	GSM5534769
Cell Line	MCF7s1r1
Tissue type	None
Disease Type	Estrogen Receptor-positive (ER+), HER2-negative
PMID	\
Initial gene number	33538
Initial cell number	2340
Post-QC gene number	6950
Post-QC cell number	1926

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	WNT7B_ligand	Epithelial,cells(Nos)_target	FZD6_LRP5_receptor	6.162e-05	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	NRP1_PLXNA1_receptor	7.430e-04	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	NRP1_PLXNA3_receptor	8.330e-04	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Good)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	PLXND1_receptor	4.648e-04	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	PLXND1_receptor	3.088e-03	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Good)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	2.648e-04	0.0	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	1.990e-03	0.0	GRN	Secreted Signaling	PMID: 29555433
Erythrocytes(Good)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	1.109e-04	0.0	GRN	Secreted Signaling	PMID: 29555433
Erythrocytes(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	5.285e-05	0.0	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	GRN_ligand	Erythrocytes(Good)_target	SORT1_receptor	1.067e-04	0.0	GRN	Secreted Signaling	PMID: 29555433
Erythrocytes(Good)_source	GRN_ligand	Erythrocytes(Good)_target	SORT1_receptor	5.939e-06	0.0	GRN	Secreted Signaling	PMID: 29555433
Erythrocytes(Nos)_source	GRN_ligand	Erythrocytes(Good)_target	SORT1_receptor	2.827e-06	0.0	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	PSAP_ligand	Epithelial,cells(Good)_target	GPR37L1_receptor	4.201e-04	0.0	PSAP	Secreted Signaling	PMID: 23690594
Erythrocytes(Nos)_source	PSAP_ligand	Epithelial,cells(Good)_target	GPR37L1_receptor	5.743e-06	0.02	PSAP	Secreted Signaling	PMID: 23690594
Epithelial,cells(Nos)_source	PSAP_ligand	Epithelial,cells(Nos)_target	GPR37L1_receptor	2.015e-03	0.0	PSAP	Secreted Signaling	PMID: 23690594
Erythrocytes(Nos)_source	PSAP_ligand	Epithelial,cells(Nos)_target	GPR37L1_receptor	2.755e-05	0.04	PSAP	Secreted Signaling	PMID: 23690594
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	1.602e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	2.269e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	5.360e-06	0.03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	5.373e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	CD44_receptor	1.635e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Good)_target	CD44_receptor	3.473e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Epithelial,cells(Good)_target	CD44_receptor	8.203e-07	0.04	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	2.316e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	5.469e-06	0.03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Erythrocytes(Good)_target	CD44_receptor	3.422e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Erythrocytes(Nos)_target	CD44_receptor	1.356e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Keratinocytes(Good)_target	CD44_receptor	4.262e-09	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Keratinocytes(Nos)_target	CD44_receptor	1.135e-08	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	1.118e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.184e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	1.280e-04	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	AGRN_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.340e-03	0.0	AGRN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	AGRN_ligand	Erythrocytes(Good)_target	DAG1_receptor	4.439e-05	0.0	AGRN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	AGRN_ligand	Erythrocytes(Nos)_target	DAG1_receptor	2.209e-05	0.01	AGRN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.500e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Erythrocytes(Nos)_target	DAG1_receptor	2.472e-05	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Good)_target	DAG1_receptor	1.429e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	2.124e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	5.017e-06	0.03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Erythrocytes(Good)_target	DAG1_receptor	7.036e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Erythrocytes(Good)_target	DAG1_receptor	1.662e-07	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Erythrocytes(Nos)_target	DAG1_receptor	3.503e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Erythrocytes(Nos)_target	DAG1_receptor	8.273e-08	0.03	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Good)_source	CD99_ligand	Epithelial,cells(Good)_target	CD99_receptor	1.048e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Epithelial,cells(Good)_target	CD99_receptor	4.734e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	1.354e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	7.280e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	3.281e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CD99_ligand	Erythrocytes(Good)_target	CD99_receptor	1.048e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	Erythrocytes(Good)_target	CD99_receptor	7.280e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	CD99_ligand	Erythrocytes(Good)_target	CD99_receptor	3.876e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Erythrocytes(Good)_target	CD99_receptor	1.738e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	4.734e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	3.281e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	1.738e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	7.777e-06	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Good)_target	CDH1_receptor	1.382e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.382e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	7.948e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB4_receptor	1.221e-04	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Erythrocytes(Good)_source	EFNB2_ligand	Epithelial,cells(Nos)_target	EPHB4_receptor	4.343e-06	0.02	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	F11R_ligand	Epithelial,cells(Nos)_target	F11R_receptor	1.797e-03	0.0	JAM	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	MPZL1_ligand	Epithelial,cells(Good)_target	MPZL1_receptor	4.441e-07	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	5.650e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	2.502e-06	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	1.568e-06	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	MPZL1_ligand	Erythrocytes(Good)_target	MPZL1_receptor	4.441e-07	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Erythrocytes(Good)_target	MPZL1_receptor	2.502e-06	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	MPZL1_ligand	Erythrocytes(Good)_target	MPZL1_receptor	1.108e-07	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	MPZL1_ligand	Erythrocytes(Good)_target	MPZL1_receptor	6.945e-08	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Erythrocytes(Nos)_target	MPZL1_receptor	1.568e-06	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Good)_source	MPZL1_ligand	Erythrocytes(Nos)_target	MPZL1_receptor	6.945e-08	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	JAG2_ligand	Epithelial,cells(Good)_target	NOTCH2_receptor	9.016e-06	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Epithelial,cells(Nos)_target	NOTCH2_receptor	9.847e-05	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Erythrocytes(Good)_target	NOTCH2_receptor	4.182e-06	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Erythrocytes(Nos)_target	NOTCH2_receptor	3.105e-06	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Epithelial,cells(Good)_target	NOTCH3_receptor	1.232e-05	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Epithelial,cells(Nos)_target	NOTCH3_receptor	1.477e-04	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Erythrocytes(Good)_target	NOTCH3_receptor	2.586e-08	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Erythrocytes(Nos)_target	NOTCH3_receptor	8.901e-09	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Keratinocytes(Good)_target	NOTCH3_receptor	6.454e-09	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Keratinocytes(Nos)_target	NOTCH3_receptor	1.503e-08	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	6.033e-05	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA4C_ligand	Epithelial,cells(Nos)_target	PLXNB2_receptor	1.236e-03	0.0	SEMA4	Cell-Cell Contact	PMID: 27533782