Sample overview
| Project Name | TARGET-RT |
| GSE ID | GSE195709 |
| GSM ID | GSM5848681 |
| Cell Line | RD cell line |
| Tissue type | None |
| Disease Type | Rhabdomyosarcoma |
| PMID | 35982179 |
| Initial gene number | 32738 |
| Initial cell number | 5466 |
| Post-QC gene number | 9751 |
| Post-QC cell number | 636 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Myocytes(Nos)_source | TGFB1_ligand | Myocytes(Nos)_target | TGFbR1_R2_receptor | 1.757e-03 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Myocytes(Nos)_source | TGFB3_ligand | Myocytes(Nos)_target | TGFbR1_R2_receptor | 1.151e-03 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Myocytes(Nos)_source | TGFB1_ligand | Myocytes(Nos)_target | ACVR1B_TGFbR2_receptor | 3.941e-04 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| Myocytes(Nos)_source | TGFB3_ligand | Myocytes(Nos)_target | ACVR1B_TGFbR2_receptor | 2.578e-04 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| Myocytes(Nos)_source | TGFB1_ligand | Myocytes(Nos)_target | ACVR1_TGFbR_receptor | 5.203e-04 | 0.0 | TGFb | Secreted Signaling | PMID: 29376829 |
| Myocytes(Nos)_source | TGFB3_ligand | Myocytes(Nos)_target | ACVR1_TGFbR_receptor | 3.404e-04 | 0.0 | TGFb | Secreted Signaling | PMID: 29376829 |
| Myocytes(Nos)_source | GDF11_ligand | Myocytes(Nos)_target | TGFBR1_ACVR2A_receptor | 1.178e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Myocytes(Nos)_source | GDF11_ligand | Myocytes(Nos)_target | TGFBR1_ACVR2B_receptor | 4.227e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Myocytes(Nos)_source | GDF11_ligand | Myocytes(Nos)_target | ACVR1B_ACVR2B_receptor | 9.448e-05 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Erythrocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | TGFBR1_ACVR2B_receptor | 2.500e-03 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Myocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | TGFBR1_ACVR2B_receptor | 3.636e-03 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Erythrocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | ACVR1B_ACVR2B_receptor | 5.624e-04 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Myocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | ACVR1B_ACVR2B_receptor | 8.201e-04 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Erythrocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | ACVR1B_ACVR2A_receptor | 1.568e-04 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Myocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | ACVR1B_ACVR2A_receptor | 2.287e-04 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Erythrocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | TGFBR1_ACVR2A_receptor | 7.007e-04 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Myocytes(Nos)_source | MSTN_ligand | Myocytes(Nos)_target | TGFBR1_ACVR2A_receptor | 1.021e-03 | 0.0 | MSTN | Secreted Signaling | KEGG: hsa04060 |
| Erythrocytes(Nos)_source | NRG1_ligand | Myocytes(Nos)_target | ERBB3_receptor | 1.078e-04 | 0.02 | NRG | Secreted Signaling | KEGG: hsa04012 |
| Myocytes(Nos)_source | NRG1_ligand | Myocytes(Nos)_target | ERBB3_receptor | 3.905e-04 | 0.0 | NRG | Secreted Signaling | KEGG: hsa04012 |
| Erythrocytes(Nos)_source | NRG1_ligand | Myocytes(Nos)_target | ERBB2_ERBB3_receptor | 4.007e-05 | 0.02 | NRG | Secreted Signaling | KEGG: hsa04012 |
| Myocytes(Nos)_source | NRG1_ligand | Myocytes(Nos)_target | ERBB2_ERBB3_receptor | 1.452e-04 | 0.0 | NRG | Secreted Signaling | KEGG: hsa04012 |
| Myocytes(Nos)_source | FGF2_ligand | Myocytes(Nos)_target | FGFR1_receptor | 6.545e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF2_ligand | Myocytes(Nos)_target | FGFR4_receptor | 5.993e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF5_ligand | Myocytes(Nos)_target | FGFR1_receptor | 1.182e-03 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF5_ligand | Myocytes(Nos)_target | FGFR4_receptor | 1.082e-03 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF9_ligand | Myocytes(Nos)_target | FGFR1_receptor | 1.253e-03 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF9_ligand | Myocytes(Nos)_target | FGFR4_receptor | 1.148e-03 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Erythrocytes(Nos)_source | IGF2_ligand | Myocytes(Nos)_target | IGF1R_receptor | 2.603e-04 | 0.0 | IGF | Secreted Signaling | PMID: 14604834 |
| Myocytes(Nos)_source | IGF2_ligand | Myocytes(Nos)_target | IGF1R_receptor | 2.538e-04 | 0.0 | IGF | Secreted Signaling | PMID: 14604834 |
| Erythrocytes(Nos)_source | IGF2_ligand | Myocytes(Nos)_target | IGF2R_receptor | 2.695e-03 | 0.0 | IGF | Secreted Signaling | PMID: 14604834 |
| Myocytes(Nos)_source | IGF2_ligand | Myocytes(Nos)_target | IGF2R_receptor | 2.619e-03 | 0.0 | IGF | Secreted Signaling | PMID: 14604834 |
| Erythrocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | SDC2_receptor | 1.627e-02 | 0.01 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | SDC2_receptor | 2.460e-02 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Erythrocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | ITGA4_ITGB1_receptor | 1.201e-02 | 0.01 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | ITGA4_ITGB1_receptor | 1.829e-02 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Erythrocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 1.356e-02 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 2.060e-02 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Erythrocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | LRP1_receptor | 1.953e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | LRP1_receptor | 3.020e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | NCL_receptor | 6.640e-02 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | NCL_receptor | 6.998e-02 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | SEMA3C_ligand | Myocytes(Nos)_target | NRP2_PLXNA1_receptor | 2.478e-04 | 0.0 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Myocytes(Nos)_source | SEMA3C_ligand | Myocytes(Nos)_target | NRP2_PLXNA2_receptor | 1.598e-04 | 0.0 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Myocytes(Nos)_source | SEMA3C_ligand | Myocytes(Nos)_target | PLXND1_receptor | 4.208e-04 | 0.0 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Myocytes(Nos)_source | GRN_ligand | Myocytes(Nos)_target | SORT1_receptor | 1.209e-03 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Myocytes(Nos)_source | FN1_ligand | Myocytes(Nos)_target | ITGA4_ITGB1_receptor | 2.310e-03 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA4_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 6.804e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB1_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 4.988e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 4.763e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA4_ligand | Myocytes(Nos)_target | ITGA7_ITGB1_receptor | 4.175e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB1_ligand | Myocytes(Nos)_target | ITGA7_ITGB1_receptor | 3.052e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | ITGA7_ITGB1_receptor | 2.914e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | FN1_ligand | Myocytes(Nos)_target | ITGAV_ITGB1_receptor | 1.760e-03 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | FN1_ligand | Myocytes(Nos)_target | CD44_receptor | 2.537e-04 | 0.02 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | FN1_ligand | Myocytes(Nos)_target | CD44_receptor | 1.064e-03 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | COL1A1_ligand | Myocytes(Nos)_target | CD44_receptor | 1.940e-04 | 0.0 | COLLAGEN | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | COL1A1_ligand | Myocytes(Nos)_target | CD44_receptor | 7.188e-04 | 0.0 | COLLAGEN | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | COL4A1_ligand | Myocytes(Nos)_target | CD44_receptor | 2.604e-03 | 0.0 | COLLAGEN | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | COL4A2_ligand | Myocytes(Nos)_target | CD44_receptor | 2.618e-03 | 0.0 | COLLAGEN | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | COL6A1_ligand | Myocytes(Nos)_target | CD44_receptor | 1.981e-03 | 0.0 | COLLAGEN | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | COL6A2_ligand | Myocytes(Nos)_target | CD44_receptor | 4.295e-04 | 0.0 | COLLAGEN | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA4_ligand | Myocytes(Nos)_target | CD44_receptor | 2.786e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB1_ligand | Myocytes(Nos)_target | CD44_receptor | 2.034e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | CD44_receptor | 1.942e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | THBS3_ligand | Myocytes(Nos)_target | CD47_receptor | 2.743e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | HSPG2_ligand | Myocytes(Nos)_target | DAG1_receptor | 1.411e-03 | 0.0 | HSPG | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA4_ligand | Myocytes(Nos)_target | DAG1_receptor | 1.043e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB1_ligand | Myocytes(Nos)_target | DAG1_receptor | 7.671e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | DAG1_receptor | 7.330e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | CD99_ligand | Myocytes(Nos)_target | CD99_receptor | 9.009e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | CDH15_ligand | Myocytes(Nos)_target | CDH15_receptor | 1.220e-02 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | CDH2_ligand | Erythrocytes(Nos)_target | CDH2_receptor | 3.877e-04 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | CDH2_ligand | Myocytes(Nos)_target | CDH2_receptor | 3.877e-04 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | CDH2_ligand | Myocytes(Nos)_target | CDH2_receptor | 1.769e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA2_receptor | 6.610e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA7_receptor | 6.156e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA2_receptor | 6.981e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA7_receptor | 6.501e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | JAM2_ligand | Myocytes(Nos)_target | ITGAV_ITGB1_receptor | 9.773e-04 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | JAM2_ligand | Myocytes(Nos)_target | JAM3_receptor | 3.545e-03 | 0.0 | JAM | Cell-Cell Contact | PMC1237098; PMID: 11590146 |
| Myocytes(Nos)_source | JAM2_ligand | Myocytes(Nos)_target | JAM2_receptor | 4.540e-04 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | JAM3_ligand | Myocytes(Nos)_target | JAM2_receptor | 3.545e-03 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | JAM3_ligand | Myocytes(Nos)_target | JAM3_receptor | 2.573e-02 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | L1CAM_ligand | Myocytes(Nos)_target | L1CAM_receptor | 7.579e-08 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Myocytes(Nos)_source | MPZL1_ligand | Myocytes(Nos)_target | MPZL1_receptor | 1.666e-04 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | NCAM1_ligand | Myocytes(Nos)_target | FGFR1_receptor | 3.738e-03 | 0.0 | NCAM | Cell-Cell Contact | PMID: 12791257 |
| Myocytes(Nos)_source | NCAM1_ligand | Erythrocytes(Nos)_target | NCAM1_receptor | 9.211e-04 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | NCAM1_ligand | Myocytes(Nos)_target | NCAM1_receptor | 9.211e-04 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | NCAM1_ligand | Myocytes(Nos)_target | NCAM1_receptor | 5.612e-03 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | NCAM1_ligand | Erythrocytes(Nos)_target | L1CAM_receptor | 1.253e-05 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | NCAM1_ligand | Myocytes(Nos)_target | L1CAM_receptor | 2.083e-05 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | DLL3_ligand | Myocytes(Nos)_target | NOTCH1_receptor | 1.840e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLL3_ligand | Myocytes(Nos)_target | NOTCH2_receptor | 2.184e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLL3_ligand | Myocytes(Nos)_target | NOTCH3_receptor | 1.514e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | JAG2_ligand | Myocytes(Nos)_target | NOTCH1_receptor | 2.733e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | JAG2_ligand | Myocytes(Nos)_target | NOTCH2_receptor | 3.243e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | JAG2_ligand | Myocytes(Nos)_target | NOTCH3_receptor | 2.249e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | SEMA6B_ligand | Myocytes(Nos)_target | PLXNA2_receptor | 2.529e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |