Sample overview
| Project Name | TARGET-RT |
| GSE ID | GSE174376 |
| GSM ID | GSM5390488 |
| Cell Line | None |
| Tissue type | None |
| Disease Type | Rhabdomyosarcoma |
| PMID | 35483358 |
| Initial gene number | 112137 |
| Initial cell number | 7889 |
| Post-QC gene number | 10116 |
| Post-QC cell number | 299 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Myocytes(Nos)_source | BMP5_ligand | Erythrocytes(Nos)_target | ACVR1_ACVR2A_receptor | 8.615e-09 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP5_ligand | Myocytes(Nos)_target | ACVR1_ACVR2A_receptor | 2.436e-05 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP5_ligand | Erythrocytes(Nos)_target | ACVR1_ACVR2B_receptor | 2.241e-08 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP5_ligand | Myocytes(Nos)_target | ACVR1_ACVR2B_receptor | 3.996e-05 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP5_ligand | Erythrocytes(Nos)_target | ACVR1_BMPR2_receptor | 1.992e-08 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP5_ligand | Myocytes(Nos)_target | ACVR1_BMPR2_receptor | 1.489e-05 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP7_ligand | Erythrocytes(Nos)_target | ACVR1_ACVR2A_receptor | 1.006e-08 | 0.02 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP7_ligand | Myocytes(Nos)_target | ACVR1_ACVR2A_receptor | 2.845e-05 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP7_ligand | Erythrocytes(Nos)_target | ACVR1_ACVR2B_receptor | 2.618e-08 | 0.02 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP7_ligand | Myocytes(Nos)_target | ACVR1_ACVR2B_receptor | 4.668e-05 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP7_ligand | Erythrocytes(Nos)_target | ACVR1_BMPR2_receptor | 2.327e-08 | 0.02 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | BMP7_ligand | Myocytes(Nos)_target | ACVR1_BMPR2_receptor | 1.740e-05 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Myocytes(Nos)_source | WNT6_ligand | Myocytes(Nos)_target | FZD2_LRP5_receptor | 3.604e-05 | 0.0 | WNT | Secreted Signaling | KEGG: hsa04310; PMID: 23209147 |
| Myocytes(Nos)_source | WNT6_ligand | Erythrocytes(Nos)_target | FZD8_LRP5_receptor | 5.776e-08 | 0.0 | WNT | Secreted Signaling | KEGG: hsa04310; PMID: 23209147 |
| Myocytes(Nos)_source | WNT6_ligand | Myocytes(Nos)_target | FZD8_LRP5_receptor | 1.914e-05 | 0.0 | WNT | Secreted Signaling | KEGG: hsa04310; PMID: 23209147 |
| Myocytes(Nos)_source | WNT6_ligand | Myocytes(Nos)_target | FZD2_LRP6_receptor | 3.559e-05 | 0.0 | WNT | Secreted Signaling | KEGG: hsa04310; PMID: 23209147 |
| Myocytes(Nos)_source | WNT6_ligand | Erythrocytes(Nos)_target | FZD8_LRP6_receptor | 9.057e-08 | 0.0 | WNT | Secreted Signaling | KEGG: hsa04310; PMID: 23209147 |
| Myocytes(Nos)_source | WNT6_ligand | Myocytes(Nos)_target | FZD8_LRP6_receptor | 1.890e-05 | 0.0 | WNT | Secreted Signaling | KEGG: hsa04310; PMID: 23209147 |
| Myocytes(Nos)_source | NRG1_ligand | Myocytes(Nos)_target | ERBB3_receptor | 8.423e-05 | 0.0 | NRG | Secreted Signaling | KEGG: hsa04012 |
| Myocytes(Nos)_source | FGF7_ligand | Myocytes(Nos)_target | FGFR1_receptor | 1.489e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF7_ligand | Myocytes(Nos)_target | FGFR2_receptor | 1.102e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF8_ligand | Myocytes(Nos)_target | FGFR1_receptor | 3.953e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF8_ligand | Myocytes(Nos)_target | FGFR2_receptor | 2.927e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF8_ligand | Myocytes(Nos)_target | FGFR3_receptor | 1.626e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF8_ligand | Myocytes(Nos)_target | FGFR4_receptor | 1.454e-03 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF9_ligand | Myocytes(Nos)_target | FGFR1_receptor | 5.389e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF9_ligand | Myocytes(Nos)_target | FGFR2_receptor | 3.991e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF9_ligand | Myocytes(Nos)_target | FGFR3_receptor | 2.218e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | FGF9_ligand | Myocytes(Nos)_target | FGFR4_receptor | 1.976e-03 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Myocytes(Nos)_source | PDGFA_ligand | Myocytes(Nos)_target | PDGFRA_receptor | 1.260e-04 | 0.0 | PDGF | Secreted Signaling | PMID: 15207812 |
| Erythrocytes(Nos)_source | IGF2_ligand | Myocytes(Nos)_target | IGF1R_receptor | 2.024e-04 | 0.0 | IGF | Secreted Signaling | PMID: 14604834 |
| Myocytes(Nos)_source | IGF2_ligand | Myocytes(Nos)_target | IGF1R_receptor | 2.703e-04 | 0.0 | IGF | Secreted Signaling | PMID: 14604834 |
| Erythrocytes(Nos)_source | MIF_ligand | Myocytes(Nos)_target | ACKR3_receptor | 6.449e-04 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Myocytes(Nos)_source | MIF_ligand | Myocytes(Nos)_target | ACKR3_receptor | 1.870e-03 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | SDC2_receptor | 4.498e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 2.121e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | LRP1_receptor | 4.434e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | NCL_receptor | 9.596e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Myocytes(Nos)_source | MDK_ligand | Myocytes(Nos)_target | ALK_receptor | 1.132e-04 | 0.0 | MK | Secreted Signaling | PMID: 19459784 |
| Myocytes(Nos)_source | NTF3_ligand | Myocytes(Nos)_target | NTRK3_receptor | 1.548e-04 | 0.0 | NT | Secreted Signaling | PMID: 27908981 |
| Myocytes(Nos)_source | GRN_ligand | Erythrocytes(Nos)_target | SORT1_receptor | 3.737e-06 | 0.01 | GRN | Secreted Signaling | PMID: 29555433 |
| Myocytes(Nos)_source | GRN_ligand | Myocytes(Nos)_target | SORT1_receptor | 1.484e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Myocytes(Nos)_source | LAMA5_ligand | Erythrocytes(Nos)_target | ITGA6_ITGB1_receptor | 2.999e-08 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA5_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 2.324e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB3_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 4.257e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | ITGA6_ITGB1_receptor | 3.094e-08 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | ITGA6_ITGB1_receptor | 2.398e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA5_ligand | Erythrocytes(Nos)_target | ITGA7_ITGB1_receptor | 3.121e-08 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA5_ligand | Myocytes(Nos)_target | ITGA7_ITGB1_receptor | 1.870e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB3_ligand | Myocytes(Nos)_target | ITGA7_ITGB1_receptor | 3.426e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | ITGA7_ITGB1_receptor | 3.221e-08 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | ITGA7_ITGB1_receptor | 1.929e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | HSPG2_ligand | Myocytes(Nos)_target | DAG1_receptor | 9.695e-08 | 0.01 | HSPG | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | HSPG2_ligand | Myocytes(Nos)_target | DAG1_receptor | 8.244e-05 | 0.0 | HSPG | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMA5_ligand | Myocytes(Nos)_target | DAG1_receptor | 8.639e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMB3_ligand | Myocytes(Nos)_target | DAG1_receptor | 1.584e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | LAMC1_ligand | Myocytes(Nos)_target | DAG1_receptor | 8.915e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Myocytes(Nos)_source | CD99_ligand | Myocytes(Nos)_target | CD99_receptor | 9.020e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | CDH15_ligand | Myocytes(Nos)_target | CDH15_receptor | 9.383e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | CDH2_ligand | Myocytes(Nos)_target | CDH2_receptor | 3.889e-09 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | CDH1_ligand | Myocytes(Nos)_target | CDH1_receptor | 7.062e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | EFNA1_ligand | Myocytes(Nos)_target | EPHA2_receptor | 6.383e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA1_ligand | Myocytes(Nos)_target | EPHA4_receptor | 8.281e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA1_ligand | Myocytes(Nos)_target | EPHA5_receptor | 5.901e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA1_ligand | Myocytes(Nos)_target | EPHA7_receptor | 2.110e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA1_ligand | Myocytes(Nos)_target | EPHA8_receptor | 1.390e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA2_receptor | 6.689e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA4_receptor | 8.677e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA5_receptor | 6.183e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA7_receptor | 2.211e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA4_ligand | Myocytes(Nos)_target | EPHA8_receptor | 1.456e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA2_receptor | 1.363e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA4_receptor | 1.768e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA5_receptor | 1.260e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA7_receptor | 4.506e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHA8_receptor | 2.965e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNA5_ligand | Myocytes(Nos)_target | EPHB2_receptor | 1.567e-06 | 0.0 | EPHA | Cell-Cell Contact | PMID:15107857; PMID: 15114347 |
| Myocytes(Nos)_source | EFNB2_ligand | Myocytes(Nos)_target | EPHA4_receptor | 7.322e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | EFNB2_ligand | Myocytes(Nos)_target | EPHB2_receptor | 6.490e-07 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Myocytes(Nos)_source | JAM3_ligand | Myocytes(Nos)_target | JAM3_receptor | 1.913e-03 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | MPZL1_ligand | Myocytes(Nos)_target | MPZL1_receptor | 3.215e-07 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | NCAM1_ligand | Myocytes(Nos)_target | FGFR1_receptor | 1.036e-03 | 0.0 | NCAM | Cell-Cell Contact | PMID: 12791257 |
| Myocytes(Nos)_source | NCAM1_ligand | Myocytes(Nos)_target | NCAM1_receptor | 3.849e-03 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Myocytes(Nos)_source | DLK1_ligand | Myocytes(Nos)_target | NOTCH1_receptor | 1.718e-03 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLK1_ligand | Myocytes(Nos)_target | NOTCH3_receptor | 1.461e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLL1_ligand | Erythrocytes(Nos)_target | NOTCH1_receptor | 8.404e-08 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLL1_ligand | Myocytes(Nos)_target | NOTCH1_receptor | 1.107e-04 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLL1_ligand | Erythrocytes(Nos)_target | NOTCH3_receptor | 2.847e-07 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | DLL1_ligand | Myocytes(Nos)_target | NOTCH3_receptor | 9.326e-06 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Myocytes(Nos)_source | SEMA6A_ligand | Myocytes(Nos)_target | PLXNA2_receptor | 1.763e-05 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Myocytes(Nos)_source | SEMA6B_ligand | Erythrocytes(Nos)_target | PLXNA2_receptor | 5.311e-09 | 0.04 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Myocytes(Nos)_source | SEMA6B_ligand | Myocytes(Nos)_target | PLXNA2_receptor | 6.188e-06 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |