Sample overview
| Project Name |
TARGET-ALL
|
| GSE ID |
GSE236136
|
| GSM ID |
GSM7518734
|
| Cell Line |
None
|
| Tissue type |
Bone Marrow;Peripheral Blood
|
| Disease Type |
B-cell acute lymphoblastic leukemia
|
| PMID |
37640845
|
| Initial gene number |
36601
|
| Initial cell number |
4223
|
| Post-QC gene number |
5561
|
| Post-QC cell number |
2070
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| B-cells(Nos)_source |
MIF_ligand |
B-cells(Nos)_target |
CD74_CXCR4_receptor |
2.238e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
B-cells(Nos)_target |
CD74_CXCR4_receptor |
1.293e-02 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CD44_receptor |
2.760e-02 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
FLT3LG_ligand |
HSC(Nos)_target |
FLT3_receptor |
2.229e-03 |
0.0 |
FLT3 |
Secreted Signaling |
PMID: 25992210 |
| B-cells(Nos)_source |
GRN_ligand |
HSC(Nos)_target |
SORT1_receptor |
3.682e-06 |
0.02 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| HSC(Nos)_source |
GRN_ligand |
HSC(Nos)_target |
SORT1_receptor |
1.691e-05 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| HSC(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
PTPRC_receptor |
4.466e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| HSC(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
CD44_receptor |
2.439e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| HSC(Nos)_source |
THBS1_ligand |
B-cells(Nos)_target |
CD47_receptor |
6.968e-05 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| HSC(Nos)_source |
THBS1_ligand |
HSC(Nos)_target |
CD47_receptor |
3.280e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| B-cells(Nos)_source |
ADGRE5_ligand |
B-cells(Nos)_target |
CD55_receptor |
5.238e-04 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| HSC(Nos)_source |
ADGRE5_ligand |
B-cells(Nos)_target |
CD55_receptor |
2.044e-03 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| B-cells(Nos)_source |
ADGRE5_ligand |
HSC(Nos)_target |
CD55_receptor |
1.745e-03 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| HSC(Nos)_source |
APP_ligand |
B-cells(Nos)_target |
CD74_receptor |
8.318e-03 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| HSC(Nos)_source |
APP_ligand |
HSC(Nos)_target |
CD74_receptor |
3.603e-02 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| HSC(Nos)_source |
APP_ligand |
Monocytes(Nos)_target |
CD74_receptor |
2.960e-03 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| HSC(Nos)_source |
CD22_ligand |
HSC(Nos)_target |
PTPRC_receptor |
3.329e-06 |
0.0 |
CD22 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
PTPRC_ligand |
HSC(Nos)_target |
CD22_receptor |
3.329e-06 |
0.0 |
CD45 |
Cell-Cell Contact |
PMID: 12115612 |
| HSC(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
2.656e-01 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
EFNA1_ligand |
HSC(Nos)_target |
EPHA4_receptor |
1.160e-04 |
0.0 |
EPHA |
Cell-Cell Contact |
PMID: 15114347 |
| B-cells(Nos)_source |
EFNB1_ligand |
B-cells(Nos)_target |
EPHA4_receptor |
7.923e-06 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| B-cells(Nos)_source |
EFNB1_ligand |
HSC(Nos)_target |
EPHA4_receptor |
4.736e-05 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| B-cells(Nos)_source |
EFNB1_ligand |
Monocytes(Nos)_target |
EPHA4_receptor |
3.396e-09 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| HSC(Nos)_source |
ESAM_ligand |
HSC(Nos)_target |
ESAM_receptor |
1.323e-03 |
0.0 |
ESAM |
Cell-Cell Contact |
KEGG: hsa04514; PMID: 11279107 |
| B-cells(Nos)_source |
ITGB2_ligand |
B-cells(Nos)_target |
ICAM2_receptor |
2.948e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ITGB2_ligand |
B-cells(Nos)_target |
ICAM2_receptor |
8.017e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
PECAM1_ligand |
HSC(Nos)_target |
PECAM1_receptor |
1.392e-02 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| B-cells(Nos)_source |
SELL_ligand |
B-cells(Nos)_target |
CD34_receptor |
1.118e-04 |
0.0 |
SELL |
Cell-Cell Contact |
PMID: 7692600; PMID: 8977216 |
| B-cells(Nos)_source |
SELL_ligand |
HSC(Nos)_target |
CD34_receptor |
2.829e-03 |
0.0 |
SELL |
Cell-Cell Contact |
PMID: 7692600; PMID: 8977216 |