Sample overview
| Project Name |
TARGET-ALL
|
| GSE ID |
GSE236136
|
| GSM ID |
GSM7518733
|
| Cell Line |
None
|
| Tissue type |
Bone Marrow;Peripheral Blood
|
| Disease Type |
B-cell acute lymphoblastic leukemia
|
| PMID |
37640845
|
| Initial gene number |
36601
|
| Initial cell number |
4557
|
| Post-QC gene number |
4623
|
| Post-QC cell number |
1957
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CXCR4_receptor |
2.287e-05 |
0.02 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CXCR4_receptor |
1.527e-03 |
0.01 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CD44_receptor |
3.593e-03 |
0.01 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
1.785e-05 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
1.194e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
MDK_ligand |
HSC(Nos)_target |
ITGA4_ITGB1_receptor |
1.289e-03 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| HSC(Nos)_source |
MDK_ligand |
HSC(Nos)_target |
ITGA6_ITGB1_receptor |
7.314e-04 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| HSC(Nos)_source |
MDK_ligand |
HSC(Nos)_target |
NCL_receptor |
6.294e-03 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| HSC(Nos)_source |
GRN_ligand |
HSC(Nos)_target |
SORT1_receptor |
7.773e-06 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Monocytes(Nos)_source |
GRN_ligand |
HSC(Nos)_target |
SORT1_receptor |
1.358e-06 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| HSC(Nos)_source |
LGALS9_ligand |
CD8+,T-cells(Nos)_target |
PTPRC_receptor |
2.642e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Nos)_source |
LGALS9_ligand |
CD8+,T-cells(Nos)_target |
PTPRC_receptor |
9.208e-06 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
PTPRC_receptor |
6.997e-05 |
0.02 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| HSC(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
PTPRC_receptor |
1.226e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
PTPRC_receptor |
4.298e-06 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
CD44_receptor |
4.353e-07 |
0.02 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| HSC(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
CD44_receptor |
9.812e-05 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
CD44_receptor |
3.442e-06 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Nos)_source |
ADGRE5_ligand |
Monocytes(Nos)_target |
CD55_receptor |
1.027e-06 |
0.02 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| HSC(Nos)_source |
APP_ligand |
HSC(Nos)_target |
CD74_receptor |
1.426e-02 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| HSC(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
1.525e-01 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ESAM_ligand |
HSC(Nos)_target |
ESAM_receptor |
2.602e-03 |
0.0 |
ESAM |
Cell-Cell Contact |
KEGG: hsa04514; PMID: 11279107 |
| CD8+,T-cells(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
7.353e-05 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
2.441e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source |
HLA-E_ligand |
CD8+,T-cells(Nos)_target |
KLRK1_receptor |
6.123e-06 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| HSC(Nos)_source |
HLA-E_ligand |
CD8+,T-cells(Nos)_target |
KLRK1_receptor |
4.087e-04 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| Monocytes(Nos)_source |
HLA-E_ligand |
CD8+,T-cells(Nos)_target |
KLRK1_receptor |
6.336e-06 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| HSC(Nos)_source |
MPZL1_ligand |
HSC(Nos)_target |
MPZL1_receptor |
3.456e-08 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source |
SELL_ligand |
HSC(Nos)_target |
CD34_receptor |
6.118e-04 |
0.0 |
SELL |
Cell-Cell Contact |
PMID: 7692600; PMID: 8977216 |
| Monocytes(Nos)_source |
SELL_ligand |
HSC(Nos)_target |
CD34_receptor |
9.705e-04 |
0.0 |
SELL |
Cell-Cell Contact |
PMID: 7692600; PMID: 8977216 |