Sample overview

Project Name	TARGET-ALL
GSE ID	GSE196214
GSM ID	GSM5862862
Cell Line	None
Tissue type	Bone Marrow
Disease Type	Relapse
PMID	\
Initial gene number	33538
Initial cell number	6182
Post-QC gene number	7770
Post-QC cell number	5711

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	TGFB1_ligand	HSC(Nos)_target	TGFbR1_R2_receptor	1.295e-05	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
CD8+,T-cells(Nos)_source	TGFB1_ligand	Monocytes(Nos)_target	TGFbR1_R2_receptor	2.405e-05	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
HSC(Nos)_source	TGFB1_ligand	Monocytes(Nos)_target	TGFbR1_R2_receptor	1.620e-04	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
Monocytes(Nos)_source	TGFB1_ligand	Monocytes(Nos)_target	TGFbR1_R2_receptor	1.426e-04	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
HSC(Nos)_source	MIF_ligand	HSC(Nos)_target	CD74_CXCR4_receptor	1.913e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
HSC(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	5.460e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Monocytes(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	4.071e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
HSC(Nos)_source	MIF_ligand	HSC(Nos)_target	CD74_CD44_receptor	5.011e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
HSC(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CD44_receptor	4.323e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
HSC(Nos)_source	NAMPT_ligand	HSC(Nos)_target	INSR_receptor	2.366e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Monocytes(Nos)_source	NAMPT_ligand	HSC(Nos)_target	INSR_receptor	1.838e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	NAMPT_ligand	HSC(Nos)_target	ITGA5_ITGB1_receptor	1.886e-04	0.04	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	NAMPT_ligand	Monocytes(Nos)_target	ITGA5_ITGB1_receptor	1.563e-04	0.01	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	MDK_ligand	HSC(Nos)_target	ITGA4_ITGB1_receptor	3.938e-03	0.0	MK	Secreted Signaling	PMID: 28356350
HSC(Nos)_source	MDK_ligand	Monocytes(Nos)_target	ITGA4_ITGB1_receptor	2.567e-03	0.0	MK	Secreted Signaling	PMID: 28356350
HSC(Nos)_source	MDK_ligand	HSC(Nos)_target	ITGA6_ITGB1_receptor	1.275e-03	0.0	MK	Secreted Signaling	PMID: 28356350
HSC(Nos)_source	MDK_ligand	Monocytes(Nos)_target	ITGA6_ITGB1_receptor	9.841e-04	0.0	MK	Secreted Signaling	PMID: 28356350
HSC(Nos)_source	MDK_ligand	HSC(Nos)_target	NCL_receptor	1.610e-02	0.0	MK	Secreted Signaling	PMID: 28356350
HSC(Nos)_source	MDK_ligand	Monocytes(Nos)_target	NCL_receptor	1.203e-02	0.0	MK	Secreted Signaling	PMID: 28356350
HSC(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	3.759e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Monocytes(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	1.180e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
HSC(Nos)_source	LGALS9_ligand	HSC(Nos)_target	CD44_receptor	9.432e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
HSC(Nos)_source	LGALS9_ligand	Monocytes(Nos)_target	CD44_receptor	8.930e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
HSC(Nos)_source	ADGRE5_ligand	Monocytes(Nos)_target	CD55_receptor	1.908e-02	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
Monocytes(Nos)_source	ADGRE5_ligand	Monocytes(Nos)_target	CD55_receptor	1.657e-02	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
Monocytes(Nos)_source	APP_ligand	HSC(Nos)_target	CD74_receptor	3.755e-03	0.0	APP	Cell-Cell Contact	PMID: 19849849
Monocytes(Nos)_source	APP_ligand	Monocytes(Nos)_target	CD74_receptor	2.958e-03	0.0	APP	Cell-Cell Contact	PMID: 19849849
HSC(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	4.267e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Monocytes(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	3.302e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CD99_ligand	Monocytes(Nos)_target	CD99_receptor	3.302e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	EFNA4_ligand	HSC(Nos)_target	EPHA7_receptor	1.314e-10	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Monocytes(Nos)_source	EFNA4_ligand	HSC(Nos)_target	EPHA7_receptor	9.388e-11	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
HSC(Nos)_source	EFNA4_ligand	Monocytes(Nos)_target	EPHA7_receptor	9.596e-11	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
HSC(Nos)_source	MPZL1_ligand	HSC(Nos)_target	MPZL1_receptor	6.928e-05	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Monocytes(Nos)_source	MPZL1_ligand	HSC(Nos)_target	MPZL1_receptor	7.513e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	MPZL1_ligand	Monocytes(Nos)_target	MPZL1_receptor	7.513e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	PECAM1_ligand	HSC(Nos)_target	PECAM1_receptor	1.306e-04	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514