Sample overview
| Project Name | TARGET-ALL |
| GSE ID | GSE196214 |
| GSM ID | GSM5862830 |
| Cell Line | None |
| Tissue type | Bone Marrow |
| Disease Type | Relapse |
| PMID | \ |
| Initial gene number | 33538 |
| Initial cell number | 4443 |
| Post-QC gene number | 4849 |
| Post-QC cell number | 4083 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| CD8+,T-cells(Good)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | PTPRC_receptor | 1.452e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Good)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | PTPRC_receptor | 1.951e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | PTPRC_receptor | 2.884e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| CD8+,T-cells(Good)_source | LGALS9_ligand | CD8+,T-cells(Poor)_target | PTPRC_receptor | 9.389e-05 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Good)_source | LGALS9_ligand | CD8+,T-cells(Poor)_target | PTPRC_receptor | 1.262e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | CD8+,T-cells(Poor)_target | PTPRC_receptor | 1.865e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| CD8+,T-cells(Good)_source | LGALS9_ligand | HSC(Nos)_target | PTPRC_receptor | 1.774e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Good)_source | LGALS9_ligand | HSC(Nos)_target | PTPRC_receptor | 2.384e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | HSC(Nos)_target | PTPRC_receptor | 3.522e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Good)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | CD44_receptor | 3.601e-07 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | CD44_receptor | 5.323e-07 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| CD8+,T-cells(Good)_source | LGALS9_ligand | CD8+,T-cells(Poor)_target | CD44_receptor | 1.990e-05 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Good)_source | LGALS9_ligand | CD8+,T-cells(Poor)_target | CD44_receptor | 2.676e-05 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | CD8+,T-cells(Poor)_target | CD44_receptor | 3.956e-05 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Good)_source | LGALS9_ligand | HSC(Good)_target | CD44_receptor | 2.197e-07 | 0.01 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | HSC(Good)_target | CD44_receptor | 3.248e-07 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Good)_source | LGALS9_ligand | HSC(Nos)_target | CD44_receptor | 3.484e-07 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | HSC(Nos)_target | CD44_receptor | 5.150e-07 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| CD8+,T-cells(Poor)_source | CD99_ligand | CD8+,T-cells(Poor)_target | CD99_receptor | 6.075e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CD99_ligand | CD8+,T-cells(Poor)_target | CD99_receptor | 7.287e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | CD8+,T-cells(Poor)_target | CD99_receptor | 1.040e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | CD99_ligand | CD8+,T-cells(Poor)_target | CD99_receptor | 2.996e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Poor)_source | CD99_ligand | HSC(Good)_target | CD99_receptor | 7.287e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | HSC(Good)_target | CD99_receptor | 1.246e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | CD99_ligand | HSC(Good)_target | CD99_receptor | 3.591e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Poor)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 1.040e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 1.246e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 1.779e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 5.128e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Poor)_source | CD99_ligand | HSC(Poor)_target | CD99_receptor | 2.996e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CD99_ligand | HSC(Poor)_target | CD99_receptor | 3.591e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | HSC(Poor)_target | CD99_receptor | 5.128e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | CD99_ligand | HSC(Poor)_target | CD99_receptor | 1.477e-03 | 0.01 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CDH2_ligand | CD8+,T-cells(Good)_target | CDH2_receptor | 1.697e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | CD8+,T-cells(Good)_target | CDH2_receptor | 1.785e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CDH2_ligand | CD8+,T-cells(Nos)_target | CDH2_receptor | 3.304e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | CD8+,T-cells(Nos)_target | CDH2_receptor | 3.474e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CDH2_ligand | CD8+,T-cells(Poor)_target | CDH2_receptor | 1.157e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Good)_source | CDH2_ligand | HSC(Good)_target | CDH2_receptor | 1.697e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CDH2_ligand | HSC(Good)_target | CDH2_receptor | 3.304e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Poor)_source | CDH2_ligand | HSC(Good)_target | CDH2_receptor | 1.157e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CDH2_ligand | HSC(Good)_target | CDH2_receptor | 4.971e-06 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | HSC(Good)_target | CDH2_receptor | 5.229e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | CDH2_ligand | HSC(Good)_target | CDH2_receptor | 7.852e-09 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Good)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 1.785e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 3.474e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 5.229e-08 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 5.499e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 8.257e-11 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | CDH2_ligand | HSC(Poor)_target | CDH2_receptor | 7.852e-09 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | HSC(Poor)_target | CDH2_receptor | 8.257e-11 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | ICAM2_ligand | CD8+,T-cells(Nos)_target | ITGAL_ITGB2_receptor | 4.306e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM2_ligand | CD8+,T-cells(Nos)_target | ITGAL_ITGB2_receptor | 7.469e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | ICAM2_ligand | CD8+,T-cells(Poor)_target | ITGAL_ITGB2_receptor | 1.855e-05 | 0.03 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | ICAM2_ligand | CD8+,T-cells(Poor)_target | ITGAL_ITGB2_receptor | 3.185e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM2_ligand | CD8+,T-cells(Poor)_target | ITGAL_ITGB2_receptor | 5.523e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | ICAM2_ligand | CD8+,T-cells(Poor)_target | ITGAL_ITGB2_receptor | 4.869e-06 | 0.02 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | ICAM2_ligand | HSC(Good)_target | ITGAL_ITGB2_receptor | 2.306e-05 | 0.01 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | ICAM2_ligand | HSC(Good)_target | ITGAL_ITGB2_receptor | 3.960e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM2_ligand | HSC(Good)_target | ITGAL_ITGB2_receptor | 6.867e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | ICAM2_ligand | HSC(Good)_target | ITGAL_ITGB2_receptor | 6.054e-06 | 0.02 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Good)_source | ICAM2_ligand | HSC(Nos)_target | ITGAL_ITGB2_receptor | 2.291e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | ICAM2_ligand | HSC(Nos)_target | ITGAL_ITGB2_receptor | 4.505e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | ICAM2_ligand | HSC(Nos)_target | ITGAL_ITGB2_receptor | 7.734e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM2_ligand | HSC(Nos)_target | ITGAL_ITGB2_receptor | 1.341e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | ICAM2_ligand | HSC(Nos)_target | ITGAL_ITGB2_receptor | 1.183e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | ICAM2_ligand | HSC(Poor)_target | ITGAL_ITGB2_receptor | 8.264e-06 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM2_ligand | HSC(Poor)_target | ITGAL_ITGB2_receptor | 1.433e-05 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | CD8+,T-cells(Good)_target | MPZL1_receptor | 4.468e-09 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | CD8+,T-cells(Nos)_target | MPZL1_receptor | 8.427e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | CD8+,T-cells(Poor)_target | MPZL1_receptor | 4.042e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | MPZL1_ligand | HSC(Good)_target | MPZL1_receptor | 4.615e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | HSC(Good)_target | MPZL1_receptor | 7.126e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Good)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 4.468e-09 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 8.427e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Poor)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 4.042e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Good)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 7.126e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 1.100e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Poor)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 2.230e-09 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | HSC(Poor)_target | MPZL1_receptor | 2.230e-09 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Good)_source | SELL_ligand | HSC(Good)_target | CD34_receptor | 4.634e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| CD8+,T-cells(Nos)_source | SELL_ligand | HSC(Good)_target | CD34_receptor | 9.995e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| CD8+,T-cells(Poor)_source | SELL_ligand | HSC(Good)_target | CD34_receptor | 6.974e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| HSC(Good)_source | SELL_ligand | HSC(Good)_target | CD34_receptor | 1.489e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| HSC(Nos)_source | SELL_ligand | HSC(Good)_target | CD34_receptor | 2.367e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| HSC(Poor)_source | SELL_ligand | HSC(Good)_target | CD34_receptor | 3.246e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| CD8+,T-cells(Good)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 5.709e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| CD8+,T-cells(Nos)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 1.231e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| CD8+,T-cells(Poor)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 8.593e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| HSC(Good)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 1.835e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| HSC(Nos)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 2.918e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| HSC(Poor)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 3.999e-05 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |