Sample overview
| Project Name | TARGET-ALL |
| GSE ID | GSE196214 |
| GSM ID | GSM5862812 |
| Cell Line | None |
| Tissue type | Bone Marrow |
| Disease Type | Relapse |
| PMID | \ |
| Initial gene number | 33538 |
| Initial cell number | 5904 |
| Post-QC gene number | 6980 |
| Post-QC cell number | 5249 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| B-cells(Nos)_source | TGFB1_ligand | B-cells(Nos)_target | ACVR1B_TGFbR2_receptor | 2.708e-07 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| HSC(Nos)_source | TGFB1_ligand | B-cells(Nos)_target | ACVR1B_TGFbR2_receptor | 2.624e-06 | 0.03 | TGFb | Secreted Signaling | PMID: 27449815 |
| NK,cells(Nos)_source | TGFB1_ligand | B-cells(Nos)_target | ACVR1B_TGFbR2_receptor | 8.734e-07 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| NK,cells(Nos)_source | TGFB1_ligand | CD4+,T-cells(Nos)_target | ACVR1B_TGFbR2_receptor | 1.774e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| B-cells(Nos)_source | TGFB1_ligand | CD8+,T-cells(Nos)_target | ACVR1B_TGFbR2_receptor | 3.091e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| NK,cells(Nos)_source | TGFB1_ligand | CD8+,T-cells(Nos)_target | ACVR1B_TGFbR2_receptor | 9.968e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| B-cells(Nos)_source | TGFB1_ligand | HSC(Nos)_target | ACVR1B_TGFbR2_receptor | 3.907e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| HSC(Nos)_source | TGFB1_ligand | HSC(Nos)_target | ACVR1B_TGFbR2_receptor | 3.785e-05 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| NK,cells(Nos)_source | TGFB1_ligand | HSC(Nos)_target | ACVR1B_TGFbR2_receptor | 1.260e-05 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| B-cells(Nos)_source | TGFB1_ligand | NK,cells(Nos)_target | ACVR1B_TGFbR2_receptor | 7.196e-07 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| CD8+,T-cells(Nos)_source | TGFB1_ligand | NK,cells(Nos)_target | ACVR1B_TGFbR2_receptor | 3.816e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| HSC(Nos)_source | TGFB1_ligand | NK,cells(Nos)_target | ACVR1B_TGFbR2_receptor | 6.972e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| NK,cells(Nos)_source | TGFB1_ligand | NK,cells(Nos)_target | ACVR1B_TGFbR2_receptor | 2.320e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| CD4+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 6.298e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 7.189e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 7.805e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 1.794e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| B-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 3.916e-08 | 0.03 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 4.250e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 4.973e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 5.422e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 1.211e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 4.238e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 4.916e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 5.352e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 1.207e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| B-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 2.921e-08 | 0.03 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 3.176e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 3.740e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 4.082e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 9.054e-06 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source | LGALS9_ligand | B-cells(Nos)_target | PTPRC_receptor | 4.135e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| CD8+,T-cells(Nos)_source | LGALS9_ligand | CD4+,T-cells(Nos)_target | PTPRC_receptor | 1.765e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | CD4+,T-cells(Nos)_target | PTPRC_receptor | 3.674e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | PTPRC_receptor | 7.827e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | HSC(Nos)_target | PTPRC_receptor | 6.846e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| CD8+,T-cells(Nos)_source | LGALS9_ligand | NK,cells(Nos)_target | PTPRC_receptor | 4.719e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| HSC(Nos)_source | LGALS9_ligand | NK,cells(Nos)_target | PTPRC_receptor | 9.815e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| CD8+,T-cells(Nos)_source | LGALS9_ligand | B-cells(Nos)_target | CD44_receptor | 9.252e-05 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | B-cells(Nos)_target | CD44_receptor | 1.979e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| CD8+,T-cells(Nos)_source | LGALS9_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 1.432e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 3.084e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | CD8+,T-cells(Nos)_target | CD44_receptor | 6.511e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | HSC(Nos)_target | CD44_receptor | 5.502e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| CD8+,T-cells(Nos)_source | LGALS9_ligand | NK,cells(Nos)_target | CD44_receptor | 1.337e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | NK,cells(Nos)_target | CD44_receptor | 2.857e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| CD4+,T-cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 7.593e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 2.371e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| HSC(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 1.751e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 6.431e-06 | 0.03 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD4+,T-cells(Nos)_source | ADGRE5_ligand | NK,cells(Nos)_target | CD55_receptor | 9.029e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | NK,cells(Nos)_target | CD55_receptor | 2.820e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| HSC(Nos)_source | ADGRE5_ligand | NK,cells(Nos)_target | CD55_receptor | 2.081e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD4+,T-cells(Nos)_source | ALCAM_ligand | CD4+,T-cells(Nos)_target | CD6_receptor | 1.365e-05 | 0.0 | ALCAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | ALCAM_ligand | CD4+,T-cells(Nos)_target | CD6_receptor | 2.581e-05 | 0.0 | ALCAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ALCAM_ligand | CD4+,T-cells(Nos)_target | CD6_receptor | 2.369e-05 | 0.0 | ALCAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | ALCAM_ligand | CD8+,T-cells(Nos)_target | CD6_receptor | 2.507e-05 | 0.0 | ALCAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | ALCAM_ligand | HSC(Nos)_target | CD6_receptor | 2.225e-05 | 0.0 | ALCAM | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 1.597e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| CD4+,T-cells(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 3.114e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| CD8+,T-cells(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 1.790e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| HSC(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 1.892e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| NK,cells(Nos)_source | APP_ligand | B-cells(Nos)_target | CD74_receptor | 4.625e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| B-cells(Nos)_source | APP_ligand | NK,cells(Nos)_target | CD74_receptor | 6.153e-07 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| CD4+,T-cells(Nos)_source | APP_ligand | NK,cells(Nos)_target | CD74_receptor | 1.199e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| CD8+,T-cells(Nos)_source | APP_ligand | NK,cells(Nos)_target | CD74_receptor | 6.896e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| HSC(Nos)_source | APP_ligand | NK,cells(Nos)_target | CD74_receptor | 7.292e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| NK,cells(Nos)_source | APP_ligand | NK,cells(Nos)_target | CD74_receptor | 1.785e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| HSC(Nos)_source | CADM1_ligand | HSC(Nos)_target | CADM1_receptor | 6.794e-05 | 0.0 | CADM | Cell-Cell Contact | PMID: 24503895 |
| CD4+,T-cells(Nos)_source | CD6_ligand | CD4+,T-cells(Nos)_target | ALCAM_receptor | 1.365e-05 | 0.0 | CD6 | Cell-Cell Contact | PMID: 23602662 |
| CD8+,T-cells(Nos)_source | CD6_ligand | CD4+,T-cells(Nos)_target | ALCAM_receptor | 2.507e-05 | 0.0 | CD6 | Cell-Cell Contact | PMID: 23602662 |
| HSC(Nos)_source | CD6_ligand | CD4+,T-cells(Nos)_target | ALCAM_receptor | 2.225e-05 | 0.0 | CD6 | Cell-Cell Contact | PMID: 23602662 |
| CD4+,T-cells(Nos)_source | CD6_ligand | CD8+,T-cells(Nos)_target | ALCAM_receptor | 2.581e-05 | 0.0 | CD6 | Cell-Cell Contact | PMID: 23602662 |
| CD4+,T-cells(Nos)_source | CD6_ligand | HSC(Nos)_target | ALCAM_receptor | 2.369e-05 | 0.0 | CD6 | Cell-Cell Contact | PMID: 23602662 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 6.904e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 6.783e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 6.783e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 6.661e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | CD4+,T-cells(Nos)_target | CDH2_receptor | 1.118e-07 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | CD8+,T-cells(Nos)_target | CDH2_receptor | 3.246e-07 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 1.118e-07 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 3.246e-07 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CDH2_ligand | HSC(Nos)_target | CDH2_receptor | 4.157e-05 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CLEC2A_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.406e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.354e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 7.980e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.431e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| HSC(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.303e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.859e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 4.064e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.419e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.518e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| HSC(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.626e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.678e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| HSC(Nos)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 9.470e-07 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | MPZL1_ligand | CD8+,T-cells(Nos)_target | MPZL1_receptor | 4.877e-07 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | CD8+,T-cells(Nos)_target | MPZL1_receptor | 3.837e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 9.470e-07 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 3.837e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 3.019e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 5.286e-08 | 0.04 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | NK,cells(Nos)_target | MPZL1_receptor | 5.286e-08 | 0.04 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 2.972e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |
| CD8+,T-cells(Nos)_source | SEMA7A_ligand | CD4+,T-cells(Nos)_target | ITGB1_ITGA1_receptor | 1.241e-04 | 0.0 | SEMA7 | Cell-Cell Contact | PMID: 22325954 |
| CD8+,T-cells(Nos)_source | SEMA7A_ligand | CD8+,T-cells(Nos)_target | ITGB1_ITGA1_receptor | 3.672e-04 | 0.0 | SEMA7 | Cell-Cell Contact | PMID: 22325954 |
| CD8+,T-cells(Nos)_source | SEMA7A_ligand | HSC(Nos)_target | ITGB1_ITGA1_receptor | 3.507e-04 | 0.0 | SEMA7 | Cell-Cell Contact | PMID: 22325954 |