Sample overview
| Project Name | MMRF-COMMPASS |
| GSE ID | GSE217245 |
| GSM ID | GSM6710025 |
| Cell Line | None |
| Tissue type | Bone Marrow |
| Disease Type | relapsed-refractory multiple myeloma |
| PMID | 36898378 |
| Initial gene number | 33539 |
| Initial cell number | 3280 |
| Post-QC gene number | 2745 |
| Post-QC cell number | 2347 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| CD4+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 1.207e-02 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 5.235e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 1.585e-02 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 6.863e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 1.401e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 6.066e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | IL16_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 5.365e-03 | 0.0 | IL16 | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | IL16_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 2.344e-03 | 0.0 | IL16 | Secreted Signaling | KEGG: hsa04060 |
| CD4+,T-cells(Nos)_source | IL16_ligand | Monocytes(Nos)_target | CD4_receptor | 8.100e-04 | 0.0 | IL16 | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | IL16_ligand | Monocytes(Nos)_target | CD4_receptor | 3.534e-04 | 0.0 | IL16 | Secreted Signaling | KEGG: hsa04060 |
| CD4+,T-cells(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 9.925e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 1.013e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 1.399e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD4+,T-cells(Nos)_target | CD99_receptor | 2.865e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.865e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.007e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | ICAM2_ligand | CD8+,T-cells(Nos)_target | ITGAL_ITGB2_receptor | 3.099e-03 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | ITGB2_ligand | CD4+,T-cells(Nos)_target | ICAM2_receptor | 6.627e-03 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ITGB2_ligand | CD4+,T-cells(Nos)_target | ICAM2_receptor | 6.242e-04 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | LCK_ligand | CD8+,T-cells(Nos)_target | CD8 receptor_receptor | 1.659e-02 | 0.0 | LCK | Cell-Cell Contact | PMID: 25427562 |
| CD8+,T-cells(Nos)_source | LCK_ligand | CD8+,T-cells(Nos)_target | CD8 receptor_receptor | 8.103e-03 | 0.0 | LCK | Cell-Cell Contact | PMID: 25427562 |
| CD4+,T-cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 3.185e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.491e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 9.187e-04 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 3.467e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.565e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.097e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 3.448e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.563e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.141e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 4.082e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.811e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.254e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-F_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.770e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-F_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 8.546e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-F_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 3.516e-04 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 3.765e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.754e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.092e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 4.085e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.837e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.297e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 4.064e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.835e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.347e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 4.778e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 2.111e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.474e-03 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | HLA-F_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 2.125e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-F_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.023e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-F_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 4.258e-04 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DPA1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 5.021e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPA1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 3.876e-04 | 0.02 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DPA1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 3.895e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPA1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 3.012e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DPA1_ligand | Monocytes(Nos)_target | CD4_receptor | 5.781e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPA1_ligand | Monocytes(Nos)_target | CD4_receptor | 4.484e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DPB1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 3.823e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPB1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 2.886e-04 | 0.02 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DPB1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 2.982e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPB1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 2.255e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DPB1_ligand | Monocytes(Nos)_target | CD4_receptor | 4.467e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPB1_ligand | Monocytes(Nos)_target | CD4_receptor | 3.388e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DMA_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 1.022e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMA_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 2.416e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DMA_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 8.075e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMA_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 1.893e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DMA_ligand | Monocytes(Nos)_target | CD4_receptor | 1.237e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMA_ligand | Monocytes(Nos)_target | CD4_receptor | 2.857e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DQB1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 6.729e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 5.068e-05 | 0.03 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DQB1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 5.327e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 4.013e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DQB1_ligand | Monocytes(Nos)_target | CD4_receptor | 8.181e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | Monocytes(Nos)_target | CD4_receptor | 6.167e-06 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRA_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 3.236e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRA_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 6.094e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRA_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 2.531e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRA_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 4.678e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRA_ligand | Monocytes(Nos)_target | CD4_receptor | 3.809e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRA_ligand | Monocytes(Nos)_target | CD4_receptor | 6.830e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRB1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 3.774e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB1_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 3.848e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRB1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 2.945e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB1_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 2.991e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRB1_ligand | Monocytes(Nos)_target | CD4_receptor | 4.413e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB1_ligand | Monocytes(Nos)_target | CD4_receptor | 4.455e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRB5_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 1.127e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB5_ligand | CD4+,T-cells(Nos)_target | CD4_receptor | 2.025e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRB5_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 8.902e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB5_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 1.590e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-DRB5_ligand | Monocytes(Nos)_target | CD4_receptor | 1.362e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB5_ligand | Monocytes(Nos)_target | CD4_receptor | 2.408e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | PECAM1_ligand | CD8+,T-cells(Nos)_target | PECAM1_receptor | 3.820e-04 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | PECAM1_ligand | CD8+,T-cells(Nos)_target | PECAM1_receptor | 5.252e-05 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | PECAM1_ligand | Monocytes(Nos)_target | PECAM1_receptor | 5.252e-05 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | PECAM1_ligand | Monocytes(Nos)_target | PECAM1_receptor | 7.205e-06 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | SELPLG_ligand | CD4+,T-cells(Nos)_target | SELL_receptor | 3.190e-02 | 0.0 | SELPLG | Cell-Cell Contact | PMC2431087; PMID: 8892633,PMID: 8896607 |